| SP | Perez, O.Perez, Odalis # >> | 25 | 2002 | L | 81 | 23 | 23 | 4 | 9 | 5.32 | .321 | 1.37 | 9.4 | 3.0 | 5.6 | 142.0 | 148 | 87 | 84 | 25 | 47 | 88 | 0 | 0 | 0 | 0 | 11 | 6 | 0 | 5.17 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 22 | 22 | 10 | 7 | 4.40 | .296 | 1.23 | 7.5 | 3.6 | 7.3 | 139.0 | 116 | 80 | 68 | 23 | 55 | 113 | 0 | 0 | 0 | 0 | 12 | 4 | 1 | 4.80 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 68 | 22 | 22 | 10 | 5 | 4.06 | .290 | 1.22 | 8.3 | 2.7 | 9.4 | 146.1 | 135 | 78 | 66 | 27 | 43 | 153 | 0 | 0 | 0 | 0 | 13 | 1 | 6 | 4.21 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 56 | 21 | 21 | 7 | 8 | 4.83 | .364 | 1.67 | 9.2 | 5.9 | 8.7 | 130.1 | 133 | 86 | 70 | 19 | 85 | 125 | 1 | 0 | 0 | 1 | 10 | 6 | 6 | 5.08 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 21 | 21 | 7 | 9 | 4.61 | .339 | 1.50 | 10.0 | 3.5 | 6.7 | 121.0 | 135 | 75 | 62 | 18 | 47 | 90 | 0 | 0 | 0 | 0 | 10 | 4 | 3 | 4.71 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 57 | 0 | 4 | 6 | 3.90 | .314 | 1.36 | 8.2 | 4.1 | 5.9 | 85.1 | 77 | 45 | 37 | 14 | 39 | 56 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 5.24 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 55 | 0 | 0 | 2 | 3.63 | .293 | 1.23 | 8.7 | 2.5 | 4.5 | 84.1 | 81 | 41 | 34 | 11 | 23 | 42 | 0 | 8 | 3 | 0 | 0 | 1 | 2 | 4.56 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 49 | 45 | 0 | 8 | 4 | 4.18 | .309 | 1.30 | 8.5 | 3.2 | 7.1 | 56.0 | 53 | 30 | 26 | 6 | 20 | 44 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 4.00 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 47 | 32 | 0 | 2 | 2 | 2.70 | .333 | 1.43 | 9.0 | 4.2 | 6.9 | 26.2 | 26 | 10 | 8 | 2 | 12 | 20 | 0 | 4 | 0 | 0 | 0 | 2 | 1 | 4.08 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 44 | 20 | 0 | 0 | 0 | 3.09 | .333 | 1.50 | 8.6 | 5.1 | 8.2 | 23.1 | 22 | 15 | 8 | 3 | 13 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.57 |