| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 18 | 18 | 1 | 5 | 5.35 | .351 | 1.61 | 9.8 | 4.7 | 6.0 | 69.0 | 75 | 46 | 41 | 18 | 36 | 46 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.67 |
| SP | Hudson, T.Hudson, Tim # >> | 28 | 2003 | R | 73 | 18 | 18 | 11 | 2 | 4.38 | .306 | 1.29 | 9.2 | 2.4 | 6.4 | 117.0 | 120 | 64 | 57 | 12 | 31 | 83 | 3 | 0 | 0 | 1 | 9 | 4 | 3 | 3.81 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 17 | 17 | 4 | 9 | 6.02 | .359 | 1.66 | 11.5 | 3.5 | 6.0 | 92.2 | 118 | 73 | 62 | 18 | 36 | 61 | 0 | 0 | 0 | 0 | 6 | 2 | 3 | 5.46 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 17 | 17 | 7 | 3 | 3.99 | .293 | 1.21 | 8.3 | 2.5 | 7.0 | 106.0 | 98 | 54 | 47 | 8 | 30 | 82 | 0 | 0 | 0 | 0 | 10 | 4 | 4 | 3.40 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 19 | 17 | 5 | 9 | 7.15 | .360 | 1.68 | 11.6 | 3.6 | 5.9 | 90.2 | 116 | 73 | 72 | 18 | 36 | 59 | 2 | 1 | 0 | 1 | 5 | 1 | 3 | 5.52 |
| RP | Dotel, O.Dotel, Octavio † >> | 29 | 2002 | R | 89 | 45 | 0 | 7 | 1 | 3.18 | .293 | 1.23 | 7.6 | 3.5 | 9.6 | 65.0 | 55 | 27 | 23 | 5 | 25 | 69 | 0 | 6 | 1 | 0 | 0 | 1 | 1 | 3.08 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 38 | 0 | 4 | 1 | 3.00 | .286 | 1.19 | 7.5 | 3.2 | 11.0 | 54.0 | 45 | 23 | 18 | 6 | 19 | 66 | 0 | 5 | 3 | 0 | 0 | 1 | 2 | 3.11 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 29 | 0 | 3 | 5 | 4.46 | .294 | 1.25 | 8.8 | 2.6 | 10.2 | 38.1 | 37 | 21 | 19 | 3 | 11 | 43 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 2.63 |
| RP | Guerrier, M.Guerrier, Matt >> | 31 | 2009 | R | 42 | 24 | 0 | 2 | 1 | 2.51 | .338 | 1.50 | 10.0 | 3.9 | 5.1 | 28.2 | 31 | 9 | 8 | 3 | 12 | 16 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 4.64 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 8 | 0 | 0 | 1 | 4.50 | .375 | 1.70 | 11.7 | 3.6 | 10.8 | 10.0 | 13 | 5 | 5 | 1 | 4 | 12 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.40 |