| SP | Santana, J.Santana, Johan $ >> | 25 | 2004 | L | 100 | 18 | 18 | 8 | 6 | 3.06 | .296 | 1.24 | 7.3 | 3.9 | 8.1 | 126.2 | 102 | 44 | 43 | 11 | 55 | 113 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 3.72 |
| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 18 | 18 | 6 | 9 | 5.32 | .334 | 1.49 | 9.8 | 3.6 | 11.9 | 111.2 | 121 | 66 | 66 | 22 | 45 | 147 | 1 | 0 | 0 | 1 | 7 | 2 | 1 | 4.20 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 82 | 17 | 17 | 7 | 5 | 4.53 | .342 | 1.53 | 9.9 | 3.9 | 7.1 | 103.1 | 113 | 59 | 52 | 14 | 45 | 81 | 1 | 0 | 0 | 0 | 11 | 3 | 3 | 4.59 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 17 | 17 | 1 | 9 | 5.62 | .336 | 1.49 | 10.6 | 2.8 | 5.5 | 99.1 | 117 | 63 | 62 | 17 | 31 | 60 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 5.05 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 19 | 17 | 5 | 6 | 6.21 | .346 | 1.55 | 11.4 | 2.7 | 6.7 | 91.1 | 115 | 67 | 63 | 18 | 27 | 68 | 0 | 0 | 0 | 0 | 7 | 3 | 1 | 5.07 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 45 | 0 | 7 | 4 | 1.76 | .278 | 1.12 | 6.9 | 3.2 | 9.4 | 51.0 | 39 | 14 | 10 | 2 | 18 | 53 | 0 | 18 | 0 | 0 | 0 | 2 | 1 | 2.61 |
| SU | Rivera, M.Rivera, Mariano $$ >> | 39 | 2008 | R | 96 | 47 | 0 | 0 | 4 | 4.02 | .273 | 1.09 | 8.4 | 1.4 | 7.9 | 56.0 | 52 | 25 | 25 | 7 | 9 | 49 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 3.46 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 48 | 0 | 1 | 1 | 3.14 | .282 | 1.18 | 7.9 | 2.8 | 9.2 | 51.2 | 45 | 18 | 18 | 9 | 16 | 52 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 35 | 0 | 5 | 0 | 3.80 | .308 | 1.31 | 8.6 | 3.2 | 6.6 | 45.0 | 43 | 20 | 19 | 1 | 16 | 33 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.96 |