| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 23 | 23 | 9 | 10 | 5.35 | .322 | 1.36 | 8.9 | 3.3 | 8.2 | 138.0 | 136 | 84 | 82 | 25 | 51 | 126 | 0 | 0 | 0 | 0 | 9 | 10 | 0 | 4.86 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 22 | 22 | 6 | 11 | 5.99 | .354 | 1.60 | 11.6 | 2.8 | 6.2 | 127.2 | 164 | 86 | 85 | 29 | 40 | 87 | 0 | 0 | 0 | 0 | 8 | 6 | 0 | 5.69 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 21 | 21 | 3 | 12 | 6.27 | .377 | 1.79 | 12.5 | 3.8 | 5.3 | 117.2 | 162 | 87 | 82 | 23 | 49 | 69 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 5.71 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 22 | 21 | 5 | 14 | 5.76 | .326 | 1.43 | 10.1 | 2.8 | 6.8 | 129.2 | 145 | 85 | 83 | 23 | 40 | 97 | 1 | 0 | 0 | 0 | 9 | 3 | 5 | 4.81 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 57 | 0 | 3 | 5 | 4.80 | .318 | 1.34 | 8.8 | 3.4 | 8.6 | 80.2 | 78 | 43 | 43 | 17 | 30 | 76 | 0 | 2 | 1 | 0 | 0 | 5 | 0 | 5.18 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 62 | 0 | 3 | 0 | 2.18 | .307 | 1.30 | 6.7 | 5.1 | 11.2 | 74.1 | 55 | 23 | 18 | 5 | 42 | 92 | 0 | 7 | 3 | 0 | 0 | 2 | 4 | 3.18 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 55 | 0 | 2 | 2 | 3.00 | .297 | 1.23 | 4.7 | 6.5 | 10.1 | 60.0 | 31 | 23 | 20 | 4 | 43 | 67 | 0 | 7 | 1 | 0 | 0 | 2 | 3 | 3.88 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 40 | 0 | 1 | 0 | 1.85 | .247 | 0.95 | 6.0 | 2.6 | 6.9 | 48.2 | 32 | 11 | 10 | 2 | 14 | 37 | 0 | 5 | 0 | 0 | 0 | 2 | 3 | 3.00 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 73 | 34 | 0 | 2 | 3 | 3.88 | .264 | 1.06 | 7.9 | 1.6 | 8.5 | 51.0 | 45 | 22 | 22 | 9 | 9 | 48 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.00 |