| SP | Clemens, R.Clemens, Roger >> | 45 | 2005 | R | 93 | 28 | 28 | 15 | 9 | 4.56 | .324 | 1.40 | 8.4 | 4.3 | 7.3 | 185.2 | 172 | 94 | 94 | 22 | 88 | 150 | 2 | 0 | 0 | 0 | 14 | 7 | 4 | 4.46 |
| SP | Pettitte, A.Pettitte, Andy # >> | 35 | 2005 | L | 84 | 28 | 28 | 11 | 13 | 3.50 | .288 | 1.18 | 8.1 | 2.5 | 5.8 | 205.2 | 185 | 84 | 80 | 26 | 58 | 131 | 4 | 0 | 0 | 2 | 16 | 6 | 2 | 4.31 |
| SP | Norris, B.Norris, Bud # >> | 29 | 2009 | R | 79 | 28 | 28 | 9 | 10 | 4.20 | .314 | 1.34 | 9.1 | 3.0 | 7.1 | 163.0 | 165 | 81 | 76 | 18 | 54 | 129 | 0 | 0 | 0 | 0 | 9 | 5 | 6 | 3.94 |
| SP | Buchholz, T.Buchholz, Taylor >> | 28 | 2006 | R | 73 | 28 | 28 | 6 | 13 | 5.23 | .339 | 1.53 | 10.6 | 3.1 | 6.1 | 155.0 | 183 | 99 | 90 | 17 | 54 | 105 | 0 | 0 | 0 | 0 | 10 | 1 | 5 | 4.14 |
| SP | Oswalt, R.Oswalt, Roy # >> | 32 | 2006 | R | 60 | 27 | 27 | 12 | 6 | 4.25 | .308 | 1.31 | 9.3 | 2.5 | 7.0 | 178.0 | 184 | 88 | 84 | 22 | 50 | 139 | 3 | 0 | 0 | 2 | 18 | 4 | 3 | 3.96 |
| RP | Dotel, O.Dotel, Octavio >> | 30 | 2003 | R | 89 | 71 | 0 | 12 | 4 | 3.65 | .305 | 1.28 | 8.3 | 3.3 | 8.9 | 91.1 | 84 | 40 | 37 | 9 | 33 | 90 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 3.49 |
| RP | Wheeler, D.Wheeler, Dan >> | 30 | 2005 | R | 82 | 69 | 0 | 3 | 1 | 3.03 | .269 | 1.06 | 7.4 | 2.2 | 8.0 | 74.1 | 61 | 26 | 25 | 7 | 18 | 66 | 0 | 5 | 2 | 0 | 0 | 3 | 0 | 3.30 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 33 | 2004 | R | 64 | 44 | 0 | 3 | 2 | 4.19 | .310 | 1.33 | 9.6 | 2.3 | 7.7 | 43.0 | 46 | 22 | 20 | 6 | 11 | 37 | 0 | 3 | 2 | 0 | 0 | 1 | 3 | 3.93 |
| RP | Qualls, C.Qualls, Chad >> | 31 | 2006 | R | 46 | 22 | 0 | 0 | 0 | 3.09 | .271 | 1.07 | 6.7 | 3.1 | 7.0 | 23.1 | 17 | 8 | 8 | 0 | 8 | 18 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.61 |
| CL | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 91 | 48 | 0 | 0 | 4 | 3.65 | .327 | 1.46 | 7.0 | 6.2 | 10.8 | 49.1 | 38 | 20 | 20 | 4 | 34 | 59 | 0 | 29 | 2 | 0 | 0 | 0 | 2 | 3.73 |
| SP | Villone, R.Villone, Ron >> | 33 | 2003 | L | 49 | 14 | 0 | 2 | 0 | 7.12 | .365 | 1.70 | 11.7 | 3.6 | 8.0 | 43.0 | 56 | 34 | 34 | 11 | 17 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.81 |