| SP | Weaver, J.Weaver, Jered >> | 26 | 2006 | R | 96 | 16 | 16 | 7 | 6 | 3.89 | .314 | 1.36 | 9.4 | 2.9 | 6.5 | 106.1 | 111 | 51 | 46 | 11 | 34 | 76 | 1 | 0 | 0 | 0 | 11 | 1 | 2 | 3.91 |
| SP | Santana, E.Santana, Ervin >> | 28 | 2008 | R | 92 | 16 | 16 | 5 | 9 | 5.67 | .336 | 1.44 | 10.8 | 2.2 | 7.3 | 98.1 | 118 | 62 | 62 | 17 | 24 | 80 | 3 | 0 | 0 | 0 | 7 | 7 | 1 | 4.57 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2006 | L | 72 | 16 | 16 | 5 | 5 | 4.99 | .335 | 1.49 | 10.2 | 3.2 | 9.5 | 97.1 | 110 | 57 | 54 | 10 | 35 | 102 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 3.38 |
| SP | Colon, B.Colon, Bartolo # >> | 33 | 2005 | R | 67 | 16 | 16 | 3 | 6 | 6.75 | .351 | 1.60 | 12.2 | 2.3 | 6.8 | 96.0 | 130 | 73 | 72 | 18 | 24 | 73 | 1 | 0 | 0 | 0 | 4 | 2 | 1 | 4.73 |
| SP | Lackey, J.Lackey, John >> | 28 | 2005 | R | 49 | 16 | 15 | 5 | 5 | 6.70 | .374 | 1.74 | 12.1 | 3.6 | 7.0 | 86.0 | 116 | 68 | 64 | 10 | 34 | 67 | 0 | 0 | 0 | 0 | 5 | 4 | 5 | 4.28 |
| RP | Arredondo, J.Arredondo, Jose >> | 27 | 2008 | R | 93 | 43 | 0 | 4 | 2 | 3.71 | .286 | 1.20 | 6.6 | 4.4 | 7.1 | 60.2 | 44 | 26 | 25 | 2 | 29 | 47 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.32 |
| RP | Speier, J.Speier, Justin >> | 33 | 2005 | R | 84 | 35 | 0 | 1 | 3 | 7.32 | .382 | 1.82 | 11.8 | 4.9 | 7.2 | 35.2 | 46 | 29 | 29 | 6 | 19 | 28 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5.34 |
| RP | Shields, S.Shields, Scot >> | 31 | 2005 | R | 77 | 23 | 0 | 3 | 1 | 3.65 | .345 | 1.58 | 9.8 | 4.9 | 8.6 | 24.2 | 26 | 12 | 10 | 3 | 13 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.33 |
| RP | Carrasco, H.Carrasco, Hector >> | 37 | 2005 | R | 68 | 18 | 0 | 1 | 1 | 4.19 | .318 | 1.40 | 8.1 | 4.7 | 6.6 | 19.1 | 17 | 9 | 9 | 0 | 10 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.11 |
| RP | Donnelly, B.Donnelly, Brendan >> | 33 | 2004 | R | 62 | 18 | 0 | 0 | 0 | 3.79 | .380 | 1.84 | 10.4 | 6.2 | 9.9 | 19.0 | 22 | 8 | 8 | 1 | 13 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.53 |
| CL | Fuentes, B.Fuentes, Brian >> | 33 | 2006 | L | 63 | 29 | 0 | 0 | 2 | 7.36 | .358 | 1.64 | 11.2 | 4.0 | 9.4 | 25.2 | 31 | 21 | 21 | 4 | 11 | 26 | 0 | 18 | 3 | 0 | 0 | 1 | 2 | 4.44 |
| SP | Escobar, K.Escobar, Kelvim >> | 28 | 2004 | R | 56 | 14 | 1 | 3 | 3 | 4.44 | .318 | 1.38 | 8.8 | 3.8 | 6.3 | 50.2 | 49 | 25 | 25 | 7 | 21 | 35 | 0 | 0 | 0 | 0 | 1 | 1 | 4 | 4.74 |