| SP | Harden, R.Harden, Rich # >> | 31 | 2008 | R | 99 | 28 | 28 | 9 | 12 | 4.64 | .340 | 1.48 | 8.5 | 4.8 | 10.0 | 159.0 | 151 | 86 | 82 | 11 | 85 | 177 | 1 | 0 | 0 | 0 | 14 | 10 | 0 | 3.47 |
| SP | Zambrano, C.Zambrano, Carlos >> | 26 | 2005 | R | 91 | 28 | 28 | 12 | 7 | 3.77 | .318 | 1.38 | 8.5 | 4.0 | 6.3 | 181.1 | 170 | 82 | 76 | 23 | 81 | 127 | 2 | 0 | 0 | 0 | 17 | 3 | 1 | 4.64 |
| SP | Prior, M.Prior, Mark # >> | 27 | 2005 | R | 86 | 29 | 20 | 4 | 11 | 5.17 | .307 | 1.30 | 8.8 | 2.9 | 8.3 | 132.1 | 129 | 76 | 76 | 19 | 43 | 121 | 1 | 2 | 0 | 0 | 8 | 4 | 4 | 4.11 |
| SP | Clement, M.Clement, Matt >> | 31 | 2004 | R | 61 | 28 | 28 | 9 | 13 | 6.01 | .330 | 1.44 | 9.1 | 3.9 | 9.6 | 130.1 | 131 | 92 | 87 | 21 | 57 | 138 | 0 | 0 | 0 | 0 | 10 | 5 | 4 | 4.41 |
| SP | Dempster, R.Dempster, Ryan >> | 35 | 2008 | R | 55 | 27 | 26 | 7 | 11 | 5.31 | .351 | 1.59 | 9.5 | 4.8 | 7.8 | 144.0 | 152 | 92 | 85 | 21 | 77 | 124 | 1 | 0 | 0 | 0 | 10 | 5 | 2 | 4.88 |
| RP | Guzman, A.Guzman, Angel >> | 33 | 2009 | R | 77 | 85 | 0 | 2 | 5 | 4.85 | .340 | 1.52 | 9.1 | 4.6 | 6.5 | 72.1 | 73 | 39 | 39 | 16 | 37 | 52 | 0 | 1 | 8 | 0 | 0 | 2 | 1 | 6.07 |
| RP | Marmol, C.Marmol, Carlos >> | 32 | 2009 | R | 71 | 67 | 0 | 6 | 2 | 5.06 | .341 | 1.55 | 8.7 | 5.4 | 9.9 | 58.2 | 56 | 34 | 33 | 7 | 35 | 64 | 0 | 2 | 1 | 0 | 0 | 0 | 6 | 4.17 |
| RP | Heilman, A.Heilman, Aaron >> | 29 | 2005 | R | 67 | 51 | 0 | 3 | 3 | 4.43 | .353 | 1.61 | 10.5 | 4.0 | 7.7 | 61.0 | 71 | 30 | 30 | 4 | 27 | 52 | 0 | 2 | 4 | 0 | 0 | 2 | 2 | 3.57 |
| RP | Gorzelanny, T.Gorzelanny, Tom >> | 32 | 2009 | L | 60 | 84 | 0 | 3 | 2 | 4.50 | .322 | 1.40 | 8.6 | 4.1 | 10.6 | 82.0 | 78 | 41 | 41 | 10 | 37 | 97 | 0 | 1 | 3 | 0 | 0 | 2 | 1 | 3.65 |
| RP | Mercker, K.Mercker, Kent >> | 37 | 2004 | L | 47 | 72 | 0 | 3 | 2 | 4.37 | .355 | 1.62 | 8.7 | 6.1 | 8.2 | 55.2 | 53 | 27 | 27 | 5 | 37 | 50 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 4.49 |