| SP | Schilling, C.Schilling, Curt >> | 38 | 2004 | R | 87 | 17 | 17 | 10 | 5 | 3.56 | .298 | 1.25 | 9.2 | 2.1 | 5.6 | 118.2 | 121 | 49 | 47 | 16 | 27 | 73 | 1 | 0 | 0 | 1 | 11 | 3 | 2 | 4.29 |
| SP | Beckett, J.Beckett, Josh # >> | 26 | 2005 | R | 87 | 16 | 16 | 6 | 5 | 4.07 | .307 | 1.29 | 9.2 | 2.4 | 7.6 | 104.0 | 106 | 48 | 47 | 14 | 28 | 88 | 1 | 0 | 0 | 0 | 9 | 4 | 2 | 3.98 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 31 | 2008 | R | 62 | 16 | 16 | 4 | 8 | 4.81 | .347 | 1.57 | 9.2 | 5.0 | 8.0 | 91.2 | 93 | 50 | 49 | 11 | 51 | 81 | 0 | 0 | 0 | 0 | 5 | 2 | 4 | 4.54 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 29 | 2007 | R | 100 | 29 | 0 | 1 | 0 | 1.00 | .206 | 0.74 | 4.3 | 2.3 | 10.3 | 27.0 | 13 | 3 | 3 | 1 | 7 | 31 | 0 | 24 | 0 | 0 | 0 | 1 | 0 | 2.07 |
| SU | Saito, T.Saito, Takashi >> | 39 | 2007 | R | 99 | 31 | 0 | 0 | 1 | 2.61 | .285 | 1.19 | 8.1 | 2.6 | 9.0 | 31.0 | 28 | 9 | 9 | 5 | 9 | 31 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.97 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 27 | 2007 | R | 94 | 38 | 0 | 7 | 3 | 1.76 | .250 | 0.98 | 5.9 | 2.9 | 10.5 | 41.0 | 27 | 8 | 8 | 0 | 13 | 48 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1.68 |
| RP | Foulke, K.Foulke, Keith >> | 32 | 2004 | R | 82 | 31 | 0 | 1 | 1 | 2.33 | .229 | 0.89 | 6.7 | 1.3 | 8.3 | 27.0 | 20 | 8 | 7 | 3 | 4 | 25 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.04 |
| RP | Okajima, H.Okajima, Hideki >> | 34 | 2007 | L | 78 | 37 | 0 | 4 | 1 | 0.78 | .207 | 0.78 | 5.1 | 2.0 | 7.0 | 23.0 | 13 | 2 | 2 | 2 | 5 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.22 |
| RP | Masterson, J.Masterson, Justin >> | 26 | 2008 | R | 74 | 21 | 0 | 3 | 2 | 1.78 | .289 | 1.15 | 7.8 | 2.7 | 5.1 | 30.1 | 26 | 6 | 6 | 0 | 9 | 17 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2.97 |
| SP | Arroyo, B.Arroyo, Bronson >> | 27 | 2004 | R | 61 | 7 | 0 | 0 | 0 | 4.21 | .294 | 1.13 | 7.9 | 2.5 | 7.6 | 25.2 | 22 | 12 | 12 | 3 | 7 | 21 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.08 |