| SP | Schilling, C.Schilling, Curt # >> | 37 | 2003 | R | 91 | 29 | 29 | 13 | 11 | 4.27 | .306 | 1.31 | 9.4 | 2.5 | 9.6 | 191.2 | 200 | 95 | 91 | 21 | 52 | 203 | 2 | 0 | 0 | 0 | 17 | 2 | 2 | 3.15 |
| SP | Beckett, J.Beckett, Josh # >> | 27 | 2005 | R | 87 | 28 | 28 | 7 | 15 | 5.10 | .335 | 1.50 | 9.1 | 4.4 | 7.3 | 181.2 | 184 | 104 | 103 | 20 | 88 | 146 | 2 | 0 | 0 | 0 | 11 | 3 | 3 | 4.33 |
| SP | Arroyo, B.Arroyo, Bronson >> | 28 | 2004 | R | 67 | 27 | 27 | 8 | 8 | 6.04 | .346 | 1.56 | 11.2 | 2.9 | 7.3 | 149.0 | 185 | 102 | 100 | 14 | 48 | 121 | 0 | 0 | 0 | 0 | 10 | 3 | 5 | 3.62 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 30 | 2007 | R | 99 | 42 | 0 | 0 | 0 | 1.52 | .279 | 1.14 | 6.1 | 4.2 | 9.4 | 41.1 | 28 | 8 | 7 | 0 | 19 | 43 | 0 | 35 | 2 | 0 | 0 | 1 | 0 | 2.37 |
| SU | Saito, T.Saito, Takashi >> | 40 | 2007 | R | 96 | 51 | 0 | 3 | 3 | 3.91 | .296 | 1.24 | 7.4 | 4.0 | 7.6 | 50.2 | 41 | 24 | 22 | 5 | 22 | 42 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 28 | 2007 | R | 94 | 77 | 0 | 3 | 3 | 2.84 | .273 | 1.06 | 5.9 | 3.7 | 9.9 | 95.0 | 62 | 30 | 30 | 10 | 39 | 104 | 0 | 1 | 1 | 0 | 0 | 6 | 0 | 3.60 |
| RP | Foulke, K.Foulke, Keith # >> | 31 | 2003 | R | 90 | 58 | 0 | 7 | 7 | 4.48 | .347 | 1.57 | 10.8 | 3.5 | 9.3 | 60.1 | 72 | 36 | 30 | 7 | 23 | 62 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Smoltz, J.Smoltz, John # >> | 36 | 2003 | R | 86 | 40 | 0 | 1 | 4 | 4.76 | .265 | 1.08 | 8.0 | 1.8 | 8.0 | 45.1 | 40 | 26 | 24 | 6 | 9 | 40 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 3.56 |
| RP | Masterson, J.Masterson, Justin >> | 27 | 2008 | R | 78 | 29 | 0 | 2 | 2 | 2.09 | .305 | 1.28 | 7.9 | 3.7 | 7.6 | 51.2 | 45 | 18 | 12 | 4 | 21 | 43 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.69 |
| RP | Timlin, M.Timlin, Mike >> | 37 | 2003 | R | 59 | 36 | 0 | 3 | 0 | 3.91 | .324 | 1.44 | 10.8 | 2.3 | 3.8 | 50.2 | 60 | 22 | 22 | 4 | 13 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.98 |