| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 28 | 28 | 6 | 11 | 4.58 | .330 | 1.45 | 10.2 | 2.9 | 9.2 | 125.2 | 142 | 72 | 64 | 18 | 40 | 128 | 0 | 0 | 0 | 0 | 0 | 4 | 9 | 3.88 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 86 | 28 | 28 | 10 | 8 | 4.94 | .329 | 1.45 | 9.7 | 3.4 | 9.6 | 191.1 | 205 | 107 | 105 | 27 | 73 | 203 | 1 | 0 | 0 | 0 | 11 | 3 | 8 | 3.91 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 27 | 27 | 12 | 5 | 5.64 | .328 | 1.44 | 10.9 | 2.1 | 6.4 | 164.1 | 198 | 103 | 103 | 30 | 39 | 116 | 1 | 0 | 0 | 0 | 14 | 4 | 1 | 4.75 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 26 | 26 | 10 | 6 | 4.05 | .313 | 1.34 | 8.2 | 3.9 | 7.0 | 164.1 | 149 | 77 | 74 | 18 | 71 | 128 | 1 | 0 | 0 | 1 | 18 | 5 | 3 | 4.26 |
| RP | Wagner, B.Wagner, Billy # >> | 32 | 2003 | L | 90 | 74 | 0 | 7 | 7 | 5.07 | .322 | 1.40 | 9.3 | 3.4 | 9.6 | 97.2 | 100 | 64 | 55 | 24 | 37 | 104 | 0 | 5 | 10 | 0 | 0 | 2 | 3 | 5.28 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 64 | 0 | 5 | 5 | 2.08 | .270 | 1.10 | 7.7 | 2.2 | 11.2 | 86.2 | 74 | 24 | 20 | 6 | 21 | 107 | 0 | 5 | 5 | 0 | 0 | 1 | 2 | 2.19 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 45 | 28 | 0 | 1 | 3 | 2.75 | .308 | 1.31 | 9.3 | 2.5 | 7.0 | 36.0 | 37 | 13 | 11 | 3 | 10 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.44 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 7 | 0 | 0 | 1 | 4.50 | .333 | 1.50 | 9.0 | 4.5 | 8.4 | 14.0 | 14 | 7 | 7 | 3 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.43 |