| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 26 | 26 | 13 | 7 | 3.64 | .315 | 1.35 | 7.4 | 4.8 | 9.5 | 150.2 | 124 | 64 | 61 | 12 | 80 | 159 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 3.60 |
| SP | Hamels, C.Hamels, Cole # >> | 25 | 2008 | L | 72 | 28 | 28 | 8 | 11 | 6.20 | .347 | 1.55 | 10.9 | 3.0 | 7.3 | 158.1 | 192 | 118 | 109 | 29 | 53 | 128 | 0 | 0 | 0 | 0 | 10 | 7 | 0 | 4.91 |
| SP | Clement, M.Clement, Matt # >> | 28 | 2002 | R | 54 | 25 | 25 | 11 | 8 | 5.68 | .336 | 1.44 | 9.2 | 3.9 | 9.1 | 142.2 | 145 | 95 | 90 | 26 | 61 | 143 | 1 | 0 | 0 | 1 | 11 | 11 | 3 | 4.89 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 70 | 0 | 7 | 2 | 3.23 | .289 | 1.18 | 8.7 | 2.0 | 9.8 | 106.0 | 102 | 40 | 38 | 12 | 23 | 115 | 0 | 6 | 2 | 0 | 0 | 4 | 4 | 3.07 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 91 | 67 | 0 | 6 | 2 | 2.27 | .257 | 1.03 | 6.1 | 3.2 | 6.3 | 91.1 | 62 | 24 | 23 | 5 | 32 | 64 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 3.40 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 57 | 0 | 4 | 2 | 2.30 | .280 | 1.15 | 5.4 | 5.0 | 10.8 | 70.1 | 42 | 18 | 18 | 3 | 39 | 84 | 0 | 13 | 2 | 0 | 0 | 1 | 6 | 2.87 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 32 | 0 | 3 | 3 | 4.07 | .315 | 1.33 | 8.1 | 3.9 | 9.0 | 42.0 | 38 | 19 | 19 | 6 | 18 | 42 | 0 | 6 | 1 | 0 | 0 | 2 | 1 | 4.29 |