| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 100 | 35 | 35 | 20 | 7 | 3.22 | .280 | 1.13 | 7.7 | 2.5 | 10.0 | 243.1 | 207 | 88 | 87 | 24 | 67 | 271 | 3 | 0 | 0 | 3 | 24 | 10 | 5 | 3.00 |
| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 93 | 34 | 34 | 14 | 12 | 4.33 | .309 | 1.32 | 9.6 | 2.3 | 10.4 | 228.2 | 244 | 117 | 110 | 32 | 58 | 263 | 4 | 0 | 0 | 1 | 17 | 5 | 5 | 3.35 |
| SP | Williams, W.Williams, Woody # >> | 36 | 2002 | R | 78 | 33 | 33 | 11 | 15 | 3.89 | .295 | 1.22 | 7.7 | 3.3 | 6.1 | 213.0 | 183 | 99 | 92 | 22 | 77 | 145 | 1 | 0 | 0 | 0 | 20 | 8 | 2 | 4.18 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 49 | 33 | 33 | 8 | 14 | 4.88 | .339 | 1.49 | 9.3 | 4.1 | 6.5 | 201.0 | 208 | 125 | 109 | 38 | 92 | 145 | 1 | 0 | 0 | 0 | 14 | 9 | 9 | 5.52 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 47 | 31 | 31 | 7 | 18 | 6.87 | .373 | 1.74 | 11.9 | 3.9 | 6.8 | 167.2 | 220 | 129 | 128 | 27 | 72 | 126 | 2 | 0 | 0 | 0 | 9 | 7 | 2 | 5.01 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 86 | 0 | 4 | 4 | 3.28 | .315 | 1.32 | 8.4 | 3.6 | 9.7 | 101.2 | 94 | 40 | 37 | 14 | 40 | 109 | 0 | 12 | 4 | 0 | 0 | 6 | 8 | 4.01 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 68 | 0 | 3 | 5 | 3.71 | .319 | 1.32 | 9.5 | 2.4 | 9.5 | 87.1 | 92 | 36 | 36 | 7 | 23 | 92 | 0 | 2 | 5 | 0 | 0 | 8 | 6 | 3.00 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 51 | 0 | 4 | 4 | 4.47 | .316 | 1.37 | 8.5 | 3.9 | 11.9 | 56.1 | 53 | 28 | 28 | 8 | 24 | 74 | 0 | 3 | 2 | 0 | 0 | 1 | 5 | 3.55 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 44 | 31 | 0 | 2 | 3 | 3.73 | .285 | 1.17 | 7.9 | 2.6 | 5.9 | 41.0 | 36 | 17 | 17 | 5 | 12 | 27 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.22 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 45 | 8 | 0 | 1 | 1 | 2.38 | .244 | 0.97 | 6.5 | 2.5 | 7.4 | 11.1 | 8 | 3 | 3 | 0 | 3 | 9 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.18 |