| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 34 | 34 | 12 | 11 | 3.62 | .295 | 1.21 | 7.8 | 3.1 | 6.4 | 221.1 | 191 | 94 | 89 | 31 | 77 | 158 | 1 | 0 | 0 | 0 | 21 | 10 | 3 | 4.57 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 33 | 33 | 11 | 15 | 4.64 | .304 | 1.27 | 8.6 | 2.8 | 9.3 | 209.2 | 200 | 115 | 108 | 30 | 66 | 216 | 2 | 0 | 0 | 1 | 16 | 9 | 6 | 3.88 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 32 | 32 | 13 | 9 | 4.42 | .343 | 1.55 | 9.2 | 4.7 | 6.9 | 189.1 | 194 | 100 | 93 | 26 | 99 | 144 | 0 | 0 | 0 | 0 | 17 | 4 | 4 | 4.90 |
| SP | Sabathia, C.Sabathia, CC # >> | 28 | 2008 | L | 60 | 32 | 32 | 8 | 16 | 5.90 | .339 | 1.48 | 10.4 | 3.0 | 8.4 | 213.2 | 245 | 145 | 140 | 40 | 72 | 198 | 5 | 0 | 0 | 0 | 9 | 12 | 4 | 4.77 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 50 | 31 | 31 | 6 | 18 | 7.27 | .378 | 1.80 | 11.3 | 4.8 | 6.6 | 166.0 | 209 | 139 | 134 | 24 | 89 | 122 | 1 | 0 | 0 | 1 | 8 | 5 | 4 | 5.11 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 84 | 0 | 2 | 7 | 3.56 | .278 | 1.12 | 7.2 | 2.9 | 10.6 | 121.1 | 97 | 52 | 48 | 14 | 39 | 143 | 0 | 7 | 4 | 0 | 0 | 4 | 0 | 3.21 |
| RP | Bailey, A.Bailey, Andrew † >> | 25 | 2009 | R | 86 | 79 | 0 | 6 | 7 | 4.65 | .323 | 1.37 | 8.4 | 3.9 | 9.6 | 98.2 | 92 | 53 | 51 | 15 | 43 | 105 | 0 | 6 | 3 | 0 | 0 | 6 | 5 | 4.35 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 45 | 0 | 4 | 2 | 4.30 | .305 | 1.27 | 8.6 | 2.9 | 10.6 | 44.0 | 42 | 23 | 21 | 5 | 14 | 52 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 3.20 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 48 | 31 | 0 | 1 | 3 | 4.03 | .274 | 1.11 | 7.6 | 2.4 | 6.9 | 38.0 | 32 | 17 | 17 | 4 | 10 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.71 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 39 | 34 | 0 | 1 | 0 | 3.52 | .285 | 1.20 | 8.0 | 2.7 | 7.6 | 46.0 | 41 | 20 | 18 | 7 | 14 | 39 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.20 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 3 | 0 | 0 | 0 | 9.82 | .421 | 2.18 | 18.0 | 6.0 | 15.0 | 3.2 | 6 | 4 | 4 | 1 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |