| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 29 | 29 | 9 | 16 | 4.51 | .326 | 1.43 | 9.7 | 3.2 | 11.1 | 201.1 | 216 | 108 | 101 | 24 | 71 | 248 | 3 | 0 | 0 | 1 | 17 | 5 | 8 | 3.22 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 29 | 29 | 2 | 7 | 5.14 | .326 | 1.40 | 9.7 | 3.0 | 7.0 | 110.1 | 118 | 67 | 63 | 18 | 37 | 85 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 4.73 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 60 | 27 | 27 | 5 | 16 | 6.23 | .358 | 1.67 | 11.5 | 3.5 | 7.0 | 160.1 | 205 | 114 | 111 | 25 | 63 | 124 | 0 | 0 | 0 | 0 | 8 | 0 | 3 | 4.66 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 28 | 26 | 7 | 10 | 6.19 | .360 | 1.65 | 11.9 | 3.0 | 6.6 | 170.0 | 224 | 119 | 117 | 28 | 56 | 124 | 3 | 1 | 0 | 0 | 9 | 7 | 2 | 4.79 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 90 | 0 | 9 | 7 | 4.54 | .323 | 1.41 | 9.7 | 3.0 | 9.0 | 121.0 | 131 | 68 | 61 | 21 | 40 | 121 | 0 | 6 | 3 | 0 | 0 | 2 | 0 | 4.30 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 78 | 0 | 6 | 7 | 5.36 | .343 | 1.51 | 8.7 | 5.0 | 10.8 | 87.1 | 84 | 58 | 52 | 11 | 48 | 104 | 0 | 2 | 4 | 0 | 0 | 5 | 5 | 4.08 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 54 | 63 | 0 | 4 | 4 | 4.24 | .318 | 1.40 | 9.6 | 3.0 | 10.9 | 74.1 | 79 | 37 | 35 | 10 | 25 | 90 | 0 | 5 | 4 | 0 | 0 | 0 | 4 | 3.34 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 60 | 0 | 4 | 2 | 2.52 | .260 | 1.03 | 6.6 | 2.6 | 5.9 | 75.0 | 55 | 23 | 21 | 9 | 22 | 49 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 4.21 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 58 | 0 | 4 | 2 | 4.83 | .291 | 1.19 | 7.2 | 3.5 | 10.0 | 69.0 | 55 | 42 | 37 | 9 | 27 | 77 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.77 |