| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 100 | 35 | 35 | 15 | 12 | 3.68 | .275 | 1.10 | 7.5 | 2.4 | 9.7 | 251.2 | 208 | 107 | 103 | 28 | 68 | 271 | 4 | 0 | 0 | 2 | 24 | 11 | 4 | 3.24 |
| SP | Hamels, C.Hamels, Cole # >> | 25 | 2008 | L | 72 | 32 | 32 | 11 | 9 | 4.95 | .316 | 1.36 | 9.4 | 2.9 | 7.3 | 202.0 | 210 | 113 | 111 | 35 | 65 | 164 | 1 | 0 | 0 | 1 | 16 | 5 | 0 | 4.67 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 54 | 31 | 31 | 12 | 6 | 6.41 | .362 | 1.65 | 10.8 | 4.1 | 7.5 | 179.2 | 214 | 128 | 128 | 24 | 82 | 149 | 0 | 0 | 0 | 0 | 13 | 10 | 4 | 4.62 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 81 | 0 | 7 | 5 | 4.47 | .332 | 1.48 | 8.3 | 5.1 | 9.9 | 100.2 | 92 | 50 | 50 | 16 | 57 | 110 | 0 | 9 | 2 | 0 | 0 | 1 | 5 | 4.62 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 68 | 0 | 7 | 5 | 4.04 | .306 | 1.30 | 8.0 | 3.8 | 8.9 | 84.2 | 75 | 39 | 38 | 14 | 35 | 83 | 0 | 9 | 7 | 0 | 0 | 2 | 5 | 4.51 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 55 | 53 | 0 | 1 | 3 | 5.23 | .329 | 1.41 | 9.7 | 3.2 | 7.4 | 51.2 | 55 | 31 | 30 | 16 | 18 | 42 | 0 | 7 | 3 | 0 | 0 | 3 | 0 | 6.67 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 44 | 45 | 0 | 2 | 4 | 3.73 | .300 | 1.24 | 8.3 | 3.1 | 7.7 | 50.2 | 46 | 23 | 21 | 5 | 17 | 43 | 0 | 0 | 4 | 0 | 0 | 2 | 0 | 3.72 |