| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 33 | 33 | 19 | 5 | 3.46 | .286 | 1.17 | 7.9 | 2.6 | 9.6 | 257.1 | 226 | 113 | 99 | 27 | 75 | 273 | 5 | 0 | 0 | 1 | 18 | 8 | 6 | 3.21 |
| SP | Vazquez, J.Vazquez, Javier # >> | 33 | 2009 | R | 87 | 32 | 32 | 10 | 11 | 5.48 | .329 | 1.42 | 9.6 | 3.2 | 9.2 | 195.1 | 207 | 130 | 119 | 33 | 70 | 200 | 3 | 0 | 0 | 1 | 10 | 10 | 1 | 4.38 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 78 | 32 | 32 | 11 | 10 | 5.77 | .348 | 1.57 | 10.7 | 3.5 | 5.1 | 179.1 | 213 | 123 | 115 | 36 | 69 | 101 | 1 | 0 | 0 | 0 | 13 | 5 | 2 | 5.73 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 32 | 32 | 14 | 6 | 4.73 | .344 | 1.56 | 10.4 | 3.7 | 5.7 | 184.2 | 212 | 110 | 97 | 27 | 76 | 117 | 1 | 0 | 0 | 0 | 16 | 3 | 0 | 4.92 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 30 | 30 | 8 | 12 | 6.96 | .367 | 1.70 | 12.3 | 3.1 | 7.2 | 157.2 | 214 | 125 | 122 | 34 | 54 | 125 | 0 | 0 | 0 | 0 | 11 | 6 | 2 | 5.37 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 90 | 0 | 9 | 3 | 3.25 | .264 | 1.06 | 7.5 | 2.0 | 10.7 | 122.0 | 102 | 45 | 44 | 14 | 27 | 145 | 0 | 5 | 7 | 0 | 0 | 2 | 2 | 2.83 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 84 | 0 | 4 | 2 | 3.36 | .252 | 0.99 | 5.4 | 3.5 | 9.0 | 99.0 | 59 | 38 | 37 | 13 | 39 | 99 | 0 | 6 | 2 | 0 | 0 | 2 | 2 | 3.95 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 76 | 0 | 4 | 0 | 1.99 | .237 | 0.93 | 6.4 | 2.0 | 6.3 | 86.0 | 61 | 21 | 19 | 7 | 19 | 60 | 0 | 10 | 2 | 0 | 0 | 0 | 2 | 3.33 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 54 | 0 | 4 | 6 | 4.12 | .314 | 1.32 | 8.5 | 3.5 | 5.8 | 54.2 | 51 | 25 | 25 | 6 | 21 | 35 | 0 | 4 | 4 | 0 | 0 | 3 | 0 | 4.48 |