| SP | Schmidt, J.Schmidt, Jason † # >> | 30 | 2003 | R | 99 | 19 | 19 | 10 | 4 | 3.23 | .271 | 1.08 | 7.3 | 2.4 | 8.9 | 136.1 | 111 | 50 | 49 | 16 | 36 | 134 | 3 | 0 | 0 | 2 | 12 | 5 | 6 | 3.46 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 18 | 18 | 3 | 7 | 6.31 | .357 | 1.61 | 10.4 | 4.1 | 7.4 | 101.1 | 117 | 73 | 71 | 18 | 46 | 83 | 0 | 0 | 0 | 0 | 6 | 6 | 1 | 5.22 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 17 | 17 | 3 | 2 | 5.50 | .345 | 1.56 | 11.3 | 2.8 | 6.5 | 72.0 | 90 | 44 | 44 | 14 | 22 | 52 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 5.08 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 73 | 19 | 17 | 5 | 3 | 4.73 | .345 | 1.55 | 10.4 | 3.6 | 6.9 | 116.0 | 134 | 64 | 61 | 21 | 46 | 89 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 5.09 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 94 | 43 | 0 | 3 | 3 | 3.30 | .319 | 1.38 | 9.6 | 2.9 | 8.0 | 46.1 | 49 | 17 | 17 | 4 | 15 | 41 | 0 | 21 | 6 | 0 | 0 | 1 | 1 | 3.39 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 38 | 0 | 5 | 3 | 4.33 | .370 | 1.74 | 9.8 | 6.1 | 6.9 | 43.2 | 47 | 21 | 21 | 6 | 29 | 33 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 5.37 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 49 | 0 | 5 | 1 | 3.86 | .275 | 1.09 | 5.1 | 4.9 | 10.6 | 46.2 | 26 | 20 | 20 | 4 | 25 | 54 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.54 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 49 | 0 | 3 | 2 | 5.61 | .348 | 1.57 | 11.2 | 3.3 | 11.5 | 33.2 | 41 | 21 | 21 | 5 | 12 | 42 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.61 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 46 | 0 | 5 | 3 | 3.91 | .245 | 0.97 | 6.6 | 2.3 | 9.4 | 48.1 | 35 | 23 | 21 | 14 | 12 | 50 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 5.46 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 29 | 0 | 1 | 1 | 3.13 | .296 | 1.26 | 7.3 | 4.4 | 6.7 | 31.2 | 25 | 11 | 11 | 2 | 15 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.81 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 43 | 0 | 1 | 2 | 4.67 | .342 | 1.56 | 8.7 | 5.6 | 8.7 | 34.2 | 33 | 19 | 18 | 2 | 21 | 33 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 3.68 |