| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 4 | 4 | 3 | 0 | 3.04 | .266 | 1.01 | 9.3 | 0.0 | 11.4 | 26.2 | 27 | 9 | 9 | 0 | 0 | 33 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 0.69 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 81 | 4 | 4 | 1 | 2 | 6.05 | .363 | 1.60 | 9.9 | 4.7 | 7.6 | 19.1 | 21 | 16 | 13 | 5 | 10 | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 6.63 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 55 | 3 | 3 | 0 | 1 | 4.11 | .324 | 1.37 | 9.0 | 3.6 | 7.2 | 15.1 | 15 | 7 | 7 | 1 | 6 | 12 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3.67 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 67 | 10 | 0 | 0 | 0 | 2.77 | .328 | 1.46 | 10.4 | 2.8 | 7.6 | 13.0 | 15 | 5 | 4 | 2 | 4 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.23 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 69 | 11 | 0 | 3 | 0 | 3.65 | .302 | 1.22 | 7.5 | 3.8 | 9.0 | 12.1 | 10 | 5 | 5 | 2 | 5 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.67 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 12 | 0 | 1 | 0 | 0.71 | .174 | 0.63 | 3.0 | 3.0 | 11.3 | 12.2 | 4 | 2 | 1 | 0 | 4 | 15 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 1.50 |
| RP | Romero, J.Romero, JoJo >> | 28 | 2025 | L | 49 | 6 | 0 | 0 | 0 | 1.17 | .207 | 0.65 | 3.9 | 2.6 | 11.6 | 7.2 | 3 | 1 | 1 | 0 | 2 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.71 |