| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 16 | 16 | 4 | 4 | 3.23 | .295 | 1.24 | 8.1 | 3.1 | 11.6 | 106.0 | 95 | 38 | 38 | 10 | 36 | 137 | 0 | 0 | 0 | 0 | 11 | 2 | 2 | 2.72 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 65 | 15 | 15 | 6 | 5 | 4.28 | .298 | 1.24 | 9.6 | 1.6 | 8.2 | 90.1 | 96 | 48 | 43 | 11 | 16 | 82 | 1 | 0 | 0 | 1 | 7 | 3 | 2 | 3.40 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 61 | 15 | 15 | 7 | 4 | 4.19 | .305 | 1.30 | 9.0 | 2.7 | 8.3 | 88.0 | 88 | 41 | 41 | 13 | 26 | 81 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 4.03 |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 44 | 0 | 3 | 1 | 3.81 | .319 | 1.37 | 9.7 | 2.6 | 10.2 | 52.0 | 56 | 29 | 22 | 8 | 15 | 59 | 0 | 4 | 6 | 0 | 0 | 2 | 1 | 3.71 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 90 | 31 | 0 | 3 | 3 | 2.75 | .276 | 1.14 | 5.8 | 4.6 | 10.8 | 39.1 | 25 | 12 | 12 | 5 | 20 | 47 | 0 | 3 | 1 | 0 | 0 | 0 | 3 | 3.79 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 26 | 0 | 1 | 3 | 1.97 | .289 | 1.19 | 7.3 | 3.4 | 8.7 | 32.0 | 26 | 8 | 7 | 1 | 12 | 31 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.69 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 75 | 24 | 0 | 3 | 1 | 1.44 | .260 | 1.02 | 6.4 | 2.9 | 9.0 | 31.1 | 22 | 5 | 5 | 1 | 10 | 31 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 2.48 |
| RP | Ferguson, C.Ferguson, Caleb >> | 28 | 2025 | L | 50 | 25 | 0 | 3 | 1 | 4.85 | .355 | 1.50 | 10.4 | 3.1 | 6.2 | 26.0 | 30 | 14 | 14 | 6 | 9 | 18 | 0 | 2 | 1 | 0 | 0 | 4 | 1 | 6.12 |
| SP | Keller, M.Keller, Mitch >> | 29 | 2025 | R | 38 | 7 | 0 | 2 | 0 | 4.50 | .333 | 1.50 | 10.5 | 3.0 | 9.8 | 12.0 | 14 | 6 | 6 | 1 | 4 | 13 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 2.92 |