| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 29 | 29 | 10 | 9 | 3.33 | .272 | 1.09 | 7.7 | 2.2 | 9.6 | 200.0 | 170 | 76 | 74 | 27 | 48 | 214 | 0 | 0 | 0 | 0 | 21 | 6 | 3 | 3.43 |
| SP | Rasmussen, D.Rasmussen, Drew # >> | 29 | 2025 | R | 83 | 28 | 28 | 11 | 7 | 3.62 | .290 | 1.19 | 7.6 | 3.2 | 7.9 | 154.1 | 130 | 64 | 62 | 27 | 54 | 135 | 0 | 0 | 0 | 0 | 10 | 5 | 2 | 4.68 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 79 | 28 | 28 | 12 | 12 | 4.36 | .294 | 1.20 | 8.8 | 2.0 | 9.7 | 192.0 | 188 | 94 | 93 | 25 | 42 | 206 | 1 | 0 | 0 | 0 | 14 | 10 | 5 | 3.36 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 64 | 27 | 27 | 10 | 10 | 4.57 | .341 | 1.51 | 8.1 | 5.5 | 10.1 | 145.2 | 131 | 76 | 74 | 22 | 89 | 163 | 0 | 0 | 0 | 0 | 9 | 6 | 5 | 4.69 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 37 | 2025 | L | 55 | 26 | 26 | 5 | 10 | 5.64 | .322 | 1.39 | 9.6 | 2.9 | 7.6 | 134.0 | 143 | 84 | 84 | 31 | 43 | 113 | 0 | 0 | 0 | 0 | 5 | 5 | 3 | 5.40 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 73 | 0 | 2 | 7 | 2.28 | .257 | 1.02 | 6.7 | 2.5 | 9.9 | 86.2 | 64 | 22 | 22 | 8 | 24 | 95 | 0 | 25 | 3 | 0 | 0 | 2 | 5 | 2.91 |
| SU | Mattson, I.Mattson, Isaac >> | 29 | 2025 | R | 62 | 69 | 0 | 3 | 3 | 2.44 | .273 | 1.11 | 5.8 | 4.2 | 9.0 | 77.1 | 50 | 21 | 21 | 6 | 36 | 77 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.45 |
| RP | Speier, G.Speier, Gabe >> | 30 | 2025 | L | 97 | 68 | 0 | 6 | 7 | 5.00 | .329 | 1.42 | 10.3 | 2.6 | 10.2 | 77.1 | 88 | 43 | 43 | 13 | 22 | 87 | 0 | 10 | 4 | 0 | 0 | 4 | 3 | 3.95 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 87 | 74 | 0 | 7 | 3 | 4.20 | .311 | 1.32 | 8.2 | 3.7 | 9.3 | 81.1 | 74 | 39 | 38 | 10 | 33 | 84 | 0 | 3 | 5 | 0 | 0 | 3 | 0 | 3.86 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 66 | 65 | 0 | 3 | 1 | 3.59 | .292 | 1.22 | 8.4 | 2.7 | 6.1 | 77.2 | 72 | 32 | 31 | 10 | 23 | 52 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.27 |