| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 99 | 20 | 20 | 13 | 4 | 3.01 | .285 | 1.18 | 7.3 | 3.3 | 8.4 | 143.2 | 116 | 48 | 48 | 11 | 53 | 134 | 1 | 0 | 0 | 0 | 13 | 3 | 6 | 3.30 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 97 | 19 | 19 | 10 | 6 | 3.35 | .270 | 1.08 | 7.1 | 2.6 | 8.9 | 147.2 | 116 | 55 | 55 | 15 | 43 | 146 | 6 | 0 | 0 | 2 | 11 | 5 | 1 | 3.32 |
| SP | Rasmussen, D.Rasmussen, Dennis >> | 33 | 1992 | L | 85 | 18 | 18 | 9 | 3 | 2.48 | .280 | 1.17 | 7.8 | 2.7 | 4.5 | 109.0 | 94 | 30 | 30 | 5 | 33 | 55 | 0 | 0 | 0 | 0 | 10 | 0 | 3 | 3.50 |
| SP | Erickson, S.Erickson, Scott >> | 24 | 1992 | R | 55 | 12 | 11 | 1 | 10 | 7.50 | .355 | 1.60 | 10.5 | 3.9 | 4.5 | 72.0 | 84 | 65 | 60 | 17 | 31 | 36 | 1 | 1 | 0 | 0 | 1 | 4 | 0 | 6.53 |
| RP | Clippard, T.Clippard, Tyler † >> | 26 | 2011 | R | 95 | 51 | 0 | 3 | 2 | 2.02 | .254 | 1.02 | 6.0 | 3.3 | 9.3 | 71.1 | 47 | 16 | 16 | 6 | 26 | 73 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 3.14 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 93 | 37 | 0 | 4 | 0 | 2.01 | .239 | 0.94 | 6.1 | 2.5 | 7.8 | 44.2 | 30 | 12 | 10 | 4 | 12 | 38 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3.27 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 86 | 18 | 0 | 3 | 0 | 0.96 | .263 | 1.07 | 7.5 | 2.5 | 7.0 | 18.2 | 15 | 4 | 2 | 0 | 5 | 14 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.28 |
| RP | Frohwirth, T.Frohwirth, Todd >> | 29 | 1991 | R | 85 | 13 | 0 | 2 | 1 | 1.29 | .176 | 0.64 | 4.5 | 1.3 | 4.5 | 14.0 | 7 | 3 | 2 | 0 | 2 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.43 |
| RP | Montgomery, J.Montgomery, Jeff >> | 27 | 1989 | R | 85 | 14 | 0 | 1 | 0 | 2.45 | .203 | 0.76 | 5.0 | 2.0 | 7.0 | 18.1 | 10 | 5 | 5 | 3 | 4 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4.28 |