| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 99 | 20 | 20 | 10 | 6 | 4.79 | .332 | 1.47 | 9.9 | 3.4 | 8.9 | 135.1 | 148 | 74 | 72 | 14 | 51 | 133 | 0 | 0 | 0 | 0 | 12 | 3 | 4 | 3.58 |
| SP | Koosman, J.Koosman, Jerry >> | 34 | 1976 | L | 83 | 19 | 19 | 4 | 9 | 4.63 | .322 | 1.41 | 10.0 | 2.7 | 6.0 | 136.0 | 151 | 73 | 70 | 13 | 41 | 91 | 3 | 0 | 0 | 0 | 9 | 2 | 1 | 3.85 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 77 | 18 | 18 | 3 | 9 | 7.05 | .369 | 1.73 | 12.1 | 3.4 | 5.8 | 106.0 | 143 | 88 | 83 | 19 | 40 | 68 | 1 | 0 | 0 | 0 | 5 | 3 | 7 | 5.26 |
| SP | Underwood, T.Underwood, Tom >> | 27 | 1980 | L | 70 | 11 | 11 | 2 | 7 | 7.62 | .405 | 2.02 | 15.1 | 3.1 | 5.9 | 52.0 | 87 | 45 | 44 | 11 | 18 | 34 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 5.54 |
| RP | Green, C.Green, Chad † >> | 26 | 2017 | R | 99 | 57 | 0 | 3 | 4 | 2.13 | .264 | 1.05 | 6.3 | 3.2 | 10.3 | 93.0 | 65 | 24 | 22 | 5 | 33 | 106 | 0 | 9 | 2 | 0 | 0 | 2 | 8 | 2.55 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 43 | 0 | 4 | 3 | 2.70 | .250 | 1.00 | 6.3 | 2.7 | 9.2 | 60.0 | 42 | 19 | 18 | 7 | 18 | 61 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 94 | 22 | 0 | 1 | 2 | 3.97 | .327 | 1.46 | 7.8 | 5.7 | 9.8 | 22.2 | 19 | 10 | 10 | 4 | 14 | 24 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5.09 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 93 | 15 | 0 | 1 | 2 | 6.11 | .369 | 1.75 | 10.6 | 5.8 | 9.0 | 17.2 | 20 | 13 | 12 | 4 | 11 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.00 |
| RP | Rocker, J.Rocker, John >> | 25 | 1999 | L | 79 | 17 | 0 | 1 | 0 | 3.48 | .326 | 1.45 | 8.1 | 5.4 | 7.2 | 20.2 | 18 | 9 | 8 | 3 | 12 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 5.15 |