| SP | Koufax, S.Koufax, Sandy † # >> | 30 | 1965 | L | 97 | 23 | 23 | 12 | 5 | 3.24 | .242 | 0.94 | 6.5 | 2.1 | 9.6 | 180.1 | 129 | 66 | 65 | 22 | 41 | 191 | 9 | 0 | 0 | 3 | 14 | 3 | 5 | 3.20 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 84 | 20 | 20 | 3 | 11 | 6.11 | .315 | 1.37 | 9.8 | 2.7 | 4.7 | 95.2 | 103 | 68 | 65 | 22 | 28 | 50 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 5.87 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 22 | 22 | 7 | 9 | 5.15 | .325 | 1.43 | 9.4 | 3.5 | 5.2 | 127.2 | 132 | 78 | 73 | 26 | 50 | 74 | 1 | 0 | 0 | 1 | 9 | 2 | 2 | 5.72 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 62 | 0 | 3 | 4 | 3.31 | .275 | 1.13 | 5.9 | 4.2 | 7.8 | 87.0 | 57 | 35 | 32 | 9 | 41 | 75 | 0 | 9 | 2 | 0 | 0 | 1 | 3 | 4.07 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 54 | 0 | 4 | 6 | 5.08 | .284 | 1.17 | 7.5 | 3.1 | 5.0 | 67.1 | 56 | 39 | 38 | 12 | 23 | 37 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 5.30 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 42 | 0 | 2 | 0 | 4.18 | .326 | 1.43 | 8.6 | 4.4 | 5.3 | 51.2 | 49 | 25 | 24 | 6 | 25 | 30 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 4.88 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 49 | 35 | 0 | 2 | 0 | 5.18 | .351 | 1.60 | 9.7 | 4.7 | 5.0 | 40.0 | 43 | 23 | 23 | 5 | 21 | 22 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 5.18 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 5 | 3 | 1 | 2 | 5.74 | .319 | 1.40 | 10.8 | 2.4 | 4.2 | 15.2 | 18 | 10 | 10 | 2 | 4 | 7 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 4.60 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 21 | 0 | 2 | 3 | 3.86 | .311 | 1.35 | 6.3 | 5.9 | 4.1 | 44.1 | 31 | 20 | 19 | 4 | 29 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.25 |