| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 24 | 24 | 11 | 10 | 2.88 | .272 | 1.10 | 7.0 | 2.8 | 7.3 | 178.0 | 139 | 62 | 57 | 16 | 56 | 145 | 6 | 0 | 0 | 4 | 17 | 5 | 1 | 3.57 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 23 | 23 | 8 | 8 | 3.40 | .287 | 1.19 | 6.4 | 4.4 | 7.3 | 161.2 | 114 | 63 | 61 | 14 | 78 | 131 | 2 | 0 | 0 | 1 | 14 | 3 | 1 | 4.01 |
| SP | Mathewson, C.Mathewson, Christy # $ >> | 28 | 1908 | R | 82 | 23 | 23 | 10 | 10 | 3.98 | .291 | 1.23 | 9.0 | 2.0 | 4.9 | 167.1 | 167 | 80 | 74 | 18 | 38 | 91 | 6 | 0 | 0 | 1 | 14 | 1 | 3 | 4.01 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 20 | 20 | 10 | 6 | 4.72 | .325 | 1.43 | 8.8 | 4.1 | 4.3 | 129.2 | 126 | 71 | 68 | 14 | 59 | 61 | 0 | 0 | 0 | 0 | 10 | 2 | 2 | 4.88 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 23 | 23 | 9 | 8 | 3.96 | .299 | 1.26 | 7.5 | 3.8 | 7.9 | 150.0 | 125 | 70 | 66 | 15 | 64 | 131 | 0 | 0 | 0 | 0 | 12 | 3 | 1 | 3.89 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 70 | 0 | 0 | 1 | 3.23 | .258 | 1.03 | 5.9 | 3.4 | 8.6 | 61.1 | 40 | 22 | 22 | 7 | 23 | 58 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.77 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 71 | 0 | 0 | 1 | 2.44 | .265 | 1.08 | 6.8 | 3.0 | 8.1 | 48.0 | 36 | 13 | 13 | 4 | 16 | 43 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 3.29 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 48 | 0 | 2 | 5 | 3.63 | .288 | 1.21 | 7.1 | 4.0 | 6.4 | 34.2 | 27 | 15 | 14 | 1 | 15 | 24 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3.29 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 29 | 0 | 5 | 3 | 4.74 | .302 | 1.30 | 8.6 | 3.4 | 10.9 | 24.2 | 23 | 13 | 13 | 3 | 9 | 29 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.33 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 44 | 0 | 3 | 0 | 2.30 | .288 | 1.21 | 7.8 | 3.2 | 5.8 | 31.1 | 27 | 8 | 8 | 3 | 11 | 20 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 4.03 |