| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 5 | 5 | 0 | 1 | 9.50 | .386 | 1.83 | 12.0 | 4.5 | 6.5 | 18.0 | 24 | 19 | 19 | 6 | 9 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.56 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 5 | 5 | 0 | 4 | 8.31 | .381 | 1.85 | 13.3 | 3.9 | 10.3 | 21.2 | 31 | 26 | 20 | 9 | 9 | 24 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7.57 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 4 | 4 | 3 | 0 | 4.30 | .330 | 1.48 | 10.2 | 3.1 | 8.2 | 23.0 | 26 | 11 | 11 | 2 | 8 | 21 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 3.35 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 4 | 4 | 1 | 1 | 9.20 | .413 | 2.05 | 12.2 | 7.1 | 5.1 | 14.2 | 19 | 15 | 15 | 3 | 11 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 7.21 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 11 | 0 | 1 | 1 | 6.23 | .328 | 1.46 | 9.0 | 4.2 | 9.0 | 13.0 | 13 | 9 | 9 | 2 | 6 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.38 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 15 | 0 | 2 | 1 | 2.45 | .267 | 1.09 | 8.2 | 1.6 | 4.5 | 22.0 | 20 | 6 | 6 | 3 | 4 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.32 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 12 | 0 | 1 | 1 | 3.63 | .325 | 1.44 | 6.9 | 6.4 | 7.9 | 17.1 | 13 | 9 | 7 | 3 | 12 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.65 |