| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 32 | 32 | 12 | 5 | 3.83 | .272 | 1.09 | 7.3 | 2.5 | 9.6 | 183.1 | 149 | 83 | 78 | 35 | 51 | 196 | 2 | 0 | 0 | 2 | 19 | 6 | 0 | 4.28 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 32 | 32 | 10 | 15 | 4.50 | .306 | 1.30 | 8.8 | 3.0 | 9.6 | 186.0 | 181 | 110 | 93 | 36 | 61 | 199 | 2 | 0 | 0 | 0 | 16 | 4 | 3 | 4.42 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 14 | 10 | 4.89 | .308 | 1.33 | 9.1 | 2.9 | 7.9 | 163.2 | 164 | 90 | 89 | 25 | 53 | 143 | 0 | 0 | 0 | 0 | 16 | 2 | 2 | 4.25 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 31 | 31 | 7 | 7 | 6.65 | .361 | 1.66 | 11.6 | 3.3 | 7.5 | 135.1 | 174 | 107 | 100 | 30 | 50 | 113 | 0 | 0 | 0 | 0 | 4 | 5 | 7 | 5.44 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 88 | 0 | 4 | 8 | 4.56 | .294 | 1.24 | 8.5 | 2.7 | 8.6 | 94.2 | 89 | 49 | 48 | 12 | 28 | 90 | 0 | 32 | 4 | 0 | 0 | 1 | 0 | 3.67 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 94 | 0 | 7 | 8 | 3.66 | .304 | 1.28 | 9.3 | 2.2 | 7.1 | 130.1 | 135 | 56 | 53 | 8 | 32 | 103 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | 3.05 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 69 | 0 | 9 | 9 | 4.59 | .312 | 1.36 | 8.6 | 3.6 | 8.9 | 100.0 | 96 | 58 | 51 | 16 | 40 | 99 | 0 | 0 | 3 | 0 | 0 | 0 | 4 | 4.30 |