| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 36 | 36 | 18 | 11 | 3.60 | .278 | 1.14 | 7.5 | 2.8 | 8.7 | 242.1 | 202 | 109 | 97 | 16 | 74 | 234 | 11 | 0 | 0 | 4 | 22 | 4 | 4 | 2.89 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 96 | 35 | 35 | 8 | 12 | 4.14 | .291 | 1.20 | 7.3 | 3.5 | 5.5 | 213.0 | 172 | 108 | 98 | 12 | 84 | 131 | 1 | 0 | 0 | 0 | 24 | 6 | 3 | 3.77 |
| SP | Johnson, R.Johnson, Randy >> | 39 | 2002 | L | 70 | 36 | 35 | 11 | 15 | 6.05 | .316 | 1.38 | 9.3 | 3.1 | 9.1 | 184.1 | 191 | 137 | 124 | 35 | 64 | 187 | 5 | 0 | 0 | 1 | 13 | 1 | 6 | 4.50 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 90 | 0 | 5 | 5 | 4.28 | .270 | 1.08 | 7.4 | 2.3 | 9.1 | 120.0 | 99 | 64 | 57 | 13 | 30 | 121 | 0 | 7 | 7 | 0 | 0 | 4 | 1 | 3.24 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 91 | 74 | 0 | 7 | 6 | 4.38 | .294 | 1.22 | 8.0 | 3.0 | 8.2 | 90.1 | 80 | 52 | 44 | 11 | 30 | 82 | 0 | 9 | 4 | 0 | 0 | 3 | 3 | 3.87 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 87 | 65 | 0 | 2 | 2 | 3.30 | .262 | 1.05 | 6.0 | 3.5 | 7.3 | 87.1 | 58 | 35 | 32 | 4 | 34 | 71 | 0 | 3 | 2 | 0 | 0 | 1 | 3 | 3.17 |
| RP | Radatz, D.Radatz, Dick >> | 27 | 1964 | R | 67 | 53 | 0 | 2 | 4 | 5.93 | .335 | 1.48 | 8.4 | 5.0 | 8.9 | 98.2 | 92 | 70 | 65 | 15 | 54 | 97 | 0 | 1 | 2 | 0 | 0 | 3 | 5 | 4.76 |
| SP | Clemens, R.Clemens, Roger >> | 28 | 1990 | R | 50 | 42 | 1 | 3 | 12 | 9.00 | .402 | 1.93 | 12.9 | 4.5 | 5.4 | 70.0 | 100 | 75 | 70 | 14 | 35 | 42 | 1 | 5 | 2 | 0 | 1 | 6 | 3 | 6.16 |