| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 10 | 10 | 7 | 2 | 2.42 | .244 | 0.96 | 6.4 | 2.1 | 9.5 | 67.0 | 48 | 18 | 18 | 6 | 16 | 71 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 2.81 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 10 | 10 | 4 | 5 | 3.66 | .260 | 1.04 | 7.1 | 2.3 | 8.3 | 66.1 | 52 | 28 | 27 | 4 | 17 | 61 | 3 | 0 | 0 | 1 | 6 | 1 | 2 | 2.76 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 9 | 9 | 1 | 4 | 5.19 | .300 | 1.27 | 8.5 | 2.9 | 6.8 | 52.0 | 49 | 30 | 30 | 8 | 17 | 39 | 1 | 0 | 0 | 0 | 4 | 1 | 3 | 4.54 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 10 | 9 | 2 | 7 | 5.10 | .314 | 1.37 | 8.3 | 4.2 | 5.7 | 54.2 | 50 | 32 | 31 | 8 | 25 | 34 | 1 | 0 | 0 | 0 | 4 | 0 | 2 | 5.06 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 30 | 0 | 1 | 1 | 4.37 | .331 | 1.49 | 9.3 | 4.1 | 11.1 | 35.0 | 36 | 17 | 17 | 1 | 16 | 43 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 2.29 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 19 | 0 | 1 | 0 | 6.33 | .347 | 1.55 | 9.0 | 5.1 | 9.4 | 21.1 | 21 | 16 | 15 | 3 | 12 | 22 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.62 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 18 | 0 | 0 | 0 | 1.64 | .258 | 1.05 | 6.1 | 3.3 | 8.2 | 22.0 | 15 | 4 | 4 | 0 | 8 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.27 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 33 | 13 | 0 | 1 | 0 | 3.26 | .247 | 0.98 | 4.7 | 4.3 | 6.2 | 19.1 | 10 | 8 | 7 | 0 | 9 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.05 |