| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 27 | 27 | 10 | 12 | 4.25 | .282 | 1.17 | 8.2 | 2.4 | 7.1 | 175.2 | 159 | 83 | 83 | 32 | 46 | 138 | 6 | 0 | 0 | 2 | 15 | 2 | 4 | 4.62 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 27 | 27 | 12 | 10 | 3.94 | .293 | 1.22 | 8.7 | 2.3 | 5.0 | 194.0 | 188 | 94 | 85 | 24 | 49 | 107 | 4 | 0 | 0 | 0 | 16 | 4 | 5 | 4.32 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 26 | 26 | 10 | 11 | 3.92 | .310 | 1.33 | 9.5 | 2.5 | 5.1 | 177.0 | 186 | 88 | 77 | 22 | 49 | 100 | 0 | 0 | 0 | 0 | 16 | 4 | 5 | 4.38 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 27 | 26 | 7 | 10 | 3.62 | .304 | 1.31 | 8.9 | 2.9 | 6.0 | 189.0 | 186 | 79 | 76 | 28 | 61 | 125 | 5 | 0 | 0 | 2 | 16 | 1 | 2 | 4.59 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 46 | 0 | 4 | 6 | 3.88 | .291 | 1.19 | 8.1 | 2.8 | 9.2 | 48.2 | 43 | 21 | 21 | 6 | 15 | 49 | 0 | 23 | 7 | 0 | 0 | 2 | 0 | 3.65 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 41 | 0 | 0 | 1 | 2.31 | .259 | 1.03 | 6.7 | 2.7 | 6.8 | 46.2 | 34 | 13 | 12 | 5 | 14 | 35 | 0 | 2 | 6 | 0 | 0 | 1 | 0 | 3.87 |
| RP | Kuo, H.Kuo, Hong-Chih † >> | 29 | 2010 | L | 91 | 66 | 0 | 6 | 3 | 3.29 | .290 | 1.22 | 7.1 | 4.0 | 9.3 | 79.1 | 62 | 34 | 29 | 8 | 35 | 82 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.57 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 46 | 0 | 2 | 3 | 6.10 | .338 | 1.49 | 8.5 | 5.1 | 6.9 | 51.2 | 48 | 36 | 35 | 13 | 29 | 39 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 6.61 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 41 | 0 | 4 | 0 | 4.40 | .283 | 1.16 | 8.0 | 2.5 | 9.0 | 43.0 | 38 | 21 | 21 | 8 | 12 | 43 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 4.33 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 31 | 0 | 0 | 0 | 3.47 | .264 | 1.07 | 7.3 | 2.5 | 8.0 | 36.1 | 29 | 15 | 14 | 5 | 10 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.86 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 6 | 1 | 1 | 1 | 5.28 | .292 | 1.24 | 8.4 | 3.0 | 4.2 | 15.1 | 14 | 9 | 9 | 1 | 5 | 7 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 3.93 |