| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 10 | 10 | 4 | 2 | 3.24 | .267 | 1.05 | 7.2 | 2.4 | 7.5 | 80.2 | 64 | 32 | 29 | 9 | 21 | 67 | 3 | 0 | 0 | 0 | 6 | 3 | 2 | 3.69 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 9 | 9 | 2 | 3 | 4.04 | .332 | 1.49 | 8.5 | 5.1 | 9.8 | 55.2 | 52 | 27 | 25 | 9 | 31 | 60 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 4.64 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 10 | 10 | 2 | 2 | 3.98 | .284 | 1.17 | 7.7 | 2.9 | 4.7 | 74.2 | 63 | 35 | 33 | 4 | 24 | 39 | 2 | 0 | 0 | 1 | 5 | 2 | 2 | 3.70 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 9 | 9 | 4 | 3 | 3.82 | .307 | 1.33 | 8.7 | 3.3 | 4.4 | 68.1 | 66 | 29 | 29 | 11 | 25 | 33 | 2 | 0 | 0 | 0 | 6 | 0 | 1 | 5.24 |
| SP | Caldwell, R.Caldwell, Ray # >> | 26 | 1914 | R | 64 | 8 | 8 | 1 | 6 | 6.33 | .341 | 1.52 | 9.8 | 3.8 | 3.8 | 54.0 | 59 | 38 | 38 | 9 | 23 | 23 | 1 | 0 | 0 | 0 | 3 | 2 | 3 | 5.70 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 25 | 0 | 3 | 2 | 2.86 | .268 | 1.07 | 7.7 | 2.1 | 6.1 | 34.2 | 29 | 12 | 11 | 4 | 8 | 23 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 3.97 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 20 | 0 | 3 | 2 | 1.59 | .277 | 1.15 | 7.4 | 3.3 | 5.7 | 22.2 | 18 | 4 | 4 | 1 | 8 | 14 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.41 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 18 | 0 | 2 | 2 | 4.00 | .280 | 1.17 | 7.5 | 3.0 | 6.5 | 18.0 | 15 | 8 | 8 | 4 | 6 | 13 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.44 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 1 | 0 | 1 | 3.00 | .308 | 1.33 | 7.5 | 4.5 | 10.5 | 6.0 | 5 | 2 | 2 | 0 | 3 | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2.17 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 3 | 0 | 1 | 0 | 6.35 | .370 | 1.59 | 12.6 | 3.6 | 5.4 | 5.2 | 7 | 4 | 4 | 2 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8.80 |