| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 6 | 3 | 2.74 | .249 | 0.98 | 7.2 | 1.7 | 11.1 | 85.1 | 68 | 30 | 26 | 9 | 16 | 105 | 1 | 0 | 0 | 1 | 9 | 1 | 0 | 2.51 |
| SP | Richard, J.Richard, J.R. # >> | 30 | 1980 | R | 90 | 14 | 13 | 6 | 3 | 4.38 | .323 | 1.42 | 8.6 | 4.1 | 9.0 | 76.0 | 73 | 39 | 37 | 4 | 35 | 76 | 0 | 0 | 0 | 0 | 9 | 1 | 3 | 3.11 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 11 | 11 | 1 | 4 | 5.42 | .322 | 1.41 | 8.4 | 4.3 | 5.4 | 73.0 | 68 | 47 | 44 | 10 | 35 | 44 | 2 | 0 | 0 | 0 | 4 | 1 | 0 | 5.05 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 11 | 11 | 8 | 2 | 3.96 | .319 | 1.37 | 9.3 | 3.0 | 6.6 | 84.0 | 87 | 38 | 37 | 5 | 28 | 62 | 0 | 0 | 0 | 0 | 5 | 3 | 3 | 3.40 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 35 | 0 | 0 | 3 | 4.93 | .333 | 1.48 | 9.4 | 3.9 | 8.6 | 42.0 | 44 | 23 | 23 | 4 | 18 | 40 | 0 | 3 | 3 | 0 | 0 | 1 | 1 | 3.69 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 13 | 0 | 0 | 2 | 2.45 | .290 | 1.16 | 5.1 | 5.8 | 12.2 | 14.2 | 8 | 4 | 4 | 2 | 9 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.29 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 14 | 0 | 0 | 1 | 2.60 | .246 | 0.98 | 6.4 | 2.6 | 10.1 | 17.1 | 12 | 6 | 5 | 2 | 5 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.18 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 10 | 0 | 0 | 0 | 8.68 | .404 | 2.04 | 10.0 | 9.0 | 9.0 | 9.1 | 10 | 9 | 9 | 1 | 9 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.44 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 20 | 0 | 0 | 2 | 4.05 | .310 | 1.35 | 10.4 | 1.8 | 7.2 | 20.0 | 23 | 10 | 9 | 3 | 4 | 16 | 0 | 9 | 4 | 0 | 0 | 0 | 0 | 3.95 |