| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 25 | 25 | 7 | 12 | 3.39 | .279 | 1.15 | 7.3 | 3.1 | 7.4 | 162.0 | 131 | 62 | 61 | 15 | 55 | 134 | 2 | 0 | 0 | 1 | 17 | 2 | 3 | 3.60 |
| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 90 | 24 | 24 | 14 | 6 | 2.48 | .270 | 1.09 | 6.3 | 3.5 | 6.9 | 174.0 | 121 | 49 | 48 | 9 | 68 | 134 | 3 | 0 | 0 | 2 | 20 | 4 | 6 | 3.37 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 82 | 23 | 23 | 15 | 5 | 2.97 | .270 | 1.11 | 8.0 | 2.0 | 5.1 | 172.2 | 152 | 58 | 57 | 16 | 39 | 97 | 5 | 0 | 0 | 1 | 18 | 1 | 1 | 3.78 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 24 | 23 | 11 | 7 | 4.49 | .296 | 1.24 | 8.6 | 2.6 | 7.8 | 140.1 | 133 | 70 | 70 | 27 | 41 | 122 | 2 | 0 | 0 | 1 | 10 | 3 | 5 | 4.71 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 64 | 0 | 5 | 2 | 2.72 | .256 | 1.00 | 5.6 | 3.4 | 7.6 | 89.1 | 55 | 28 | 27 | 8 | 34 | 75 | 0 | 5 | 2 | 0 | 0 | 3 | 8 | 3.73 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 56 | 0 | 3 | 3 | 2.76 | .294 | 1.25 | 6.3 | 5.0 | 9.3 | 78.1 | 55 | 26 | 24 | 3 | 43 | 81 | 0 | 11 | 2 | 0 | 0 | 0 | 0 | 3.08 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 43 | 0 | 2 | 2 | 3.04 | .283 | 1.18 | 7.9 | 2.9 | 6.5 | 47.1 | 41 | 16 | 16 | 2 | 15 | 34 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3.06 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 29 | 0 | 3 | 2 | 1.10 | .252 | 1.01 | 4.8 | 4.5 | 8.4 | 32.2 | 17 | 5 | 4 | 1 | 16 | 30 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.03 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 19 | 0 | 2 | 1 | 1.64 | .258 | 1.05 | 6.1 | 3.3 | 6.1 | 22.0 | 15 | 4 | 4 | 2 | 8 | 15 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.91 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 17 | 0 | 1 | 0 | 5.00 | .308 | 1.33 | 7.5 | 4.5 | 6.5 | 18.0 | 15 | 10 | 10 | 2 | 9 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |