| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 29 | 29 | 15 | 12 | 3.18 | .265 | 1.06 | 7.2 | 2.3 | 7.6 | 220.2 | 177 | 81 | 78 | 14 | 57 | 185 | 13 | 0 | 0 | 4 | 17 | 5 | 0 | 2.99 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 28 | 28 | 10 | 11 | 5.09 | .318 | 1.39 | 9.6 | 2.9 | 3.8 | 187.1 | 200 | 110 | 106 | 23 | 60 | 79 | 6 | 0 | 0 | 2 | 10 | 2 | 4 | 4.75 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 28 | 28 | 11 | 13 | 4.54 | .322 | 1.41 | 9.7 | 3.0 | 4.1 | 198.1 | 214 | 107 | 100 | 20 | 66 | 91 | 7 | 0 | 0 | 0 | 13 | 2 | 6 | 4.42 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 28 | 28 | 13 | 11 | 4.00 | .288 | 1.18 | 9.0 | 1.7 | 4.2 | 218.0 | 217 | 104 | 97 | 26 | 41 | 102 | 11 | 0 | 0 | 0 | 16 | 7 | 7 | 4.28 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 27 | 27 | 5 | 7 | 5.25 | .346 | 1.57 | 9.4 | 4.8 | 8.4 | 130.1 | 136 | 78 | 76 | 9 | 69 | 122 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 3.66 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 71 | 0 | 6 | 4 | 3.90 | .309 | 1.32 | 8.7 | 3.2 | 8.7 | 90.0 | 87 | 45 | 39 | 9 | 32 | 87 | 0 | 8 | 4 | 0 | 0 | 2 | 2 | 3.50 |
| RP | Boxberger, B.Boxberger, Brad # >> | 26 | 2014 | R | 83 | 57 | 0 | 2 | 3 | 4.66 | .316 | 1.36 | 7.5 | 4.8 | 9.5 | 67.2 | 56 | 43 | 35 | 8 | 36 | 71 | 0 | 6 | 3 | 0 | 0 | 2 | 2 | 4.13 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 42 | 0 | 3 | 8 | 5.80 | .339 | 1.52 | 10.3 | 3.6 | 4.3 | 63.2 | 72 | 50 | 41 | 19 | 25 | 30 | 0 | 5 | 4 | 0 | 0 | 1 | 4 | 7.21 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 4 | 0 | 0 | 1 | 8.53 | .441 | 2.21 | 15.0 | 6.0 | 6.0 | 6.1 | 10 | 6 | 6 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.17 |