| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 28 | 28 | 8 | 11 | 3.49 | .281 | 1.16 | 7.1 | 3.4 | 8.4 | 198.1 | 156 | 80 | 77 | 23 | 74 | 185 | 1 | 0 | 0 | 0 | 19 | 3 | 4 | 3.81 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 28 | 28 | 7 | 16 | 4.54 | .307 | 1.32 | 9.3 | 2.6 | 5.1 | 220.0 | 227 | 121 | 111 | 25 | 63 | 125 | 6 | 0 | 0 | 1 | 11 | 3 | 3 | 4.24 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 27 | 27 | 11 | 7 | 4.51 | .297 | 1.27 | 9.1 | 2.4 | 4.5 | 151.2 | 152 | 77 | 76 | 21 | 40 | 75 | 0 | 0 | 0 | 0 | 11 | 0 | 2 | 4.61 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 77 | 27 | 27 | 8 | 15 | 5.93 | .341 | 1.52 | 11.4 | 2.4 | 5.2 | 189.2 | 239 | 135 | 125 | 40 | 50 | 110 | 9 | 0 | 0 | 0 | 9 | 5 | 1 | 5.46 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 27 | 27 | 12 | 9 | 4.04 | .307 | 1.31 | 8.6 | 3.2 | 4.9 | 178.0 | 170 | 83 | 80 | 19 | 64 | 96 | 0 | 0 | 0 | 0 | 15 | 3 | 3 | 4.44 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 69 | 0 | 4 | 4 | 2.50 | .230 | 0.88 | 5.5 | 2.5 | 8.6 | 97.1 | 59 | 27 | 27 | 8 | 27 | 93 | 0 | 5 | 6 | 0 | 0 | 1 | 1 | 3.02 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 66 | 0 | 4 | 5 | 2.64 | .299 | 1.28 | 9.7 | 1.8 | 7.7 | 78.1 | 84 | 27 | 23 | 6 | 16 | 67 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 2.90 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 47 | 0 | 5 | 3 | 3.98 | .268 | 1.08 | 8.7 | 1.0 | 8.0 | 52.0 | 50 | 24 | 23 | 6 | 6 | 46 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 3.13 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 24 | 0 | 1 | 2 | 1.61 | .243 | 0.96 | 7.7 | 1.0 | 8.4 | 28.0 | 24 | 5 | 5 | 1 | 3 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.93 |