| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 29 | 29 | 11 | 9 | 3.26 | .271 | 1.10 | 7.1 | 2.8 | 8.2 | 193.0 | 152 | 75 | 70 | 18 | 60 | 175 | 6 | 0 | 0 | 2 | 19 | 3 | 5 | 3.38 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 28 | 28 | 15 | 7 | 3.61 | .305 | 1.29 | 8.7 | 2.9 | 7.1 | 192.0 | 186 | 85 | 77 | 19 | 62 | 152 | 1 | 0 | 0 | 1 | 18 | 5 | 7 | 3.75 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 28 | 28 | 13 | 9 | 4.53 | .301 | 1.27 | 8.9 | 2.5 | 8.7 | 175.0 | 174 | 89 | 88 | 19 | 48 | 169 | 4 | 0 | 0 | 1 | 15 | 4 | 10 | 3.37 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 56 | 0 | 5 | 1 | 2.79 | .267 | 1.05 | 6.6 | 3.0 | 8.9 | 67.2 | 49 | 23 | 21 | 3 | 22 | 66 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 2.73 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 24 | 0 | 2 | 1 | 1.86 | .281 | 1.14 | 6.5 | 3.7 | 7.4 | 29.0 | 21 | 6 | 6 | 0 | 12 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.69 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 31 | 0 | 1 | 3 | 4.96 | .338 | 1.50 | 8.4 | 5.3 | 9.8 | 32.2 | 30 | 23 | 18 | 2 | 19 | 35 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 3.50 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 43 | 0 | 1 | 0 | 1.93 | .227 | 0.86 | 5.4 | 2.4 | 10.1 | 42.0 | 25 | 11 | 9 | 4 | 11 | 47 | 0 | 37 | 0 | 0 | 0 | 1 | 0 | 2.86 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 14 | 0 | 2 | 3 | 5.02 | .316 | 1.36 | 9.1 | 3.1 | 6.4 | 66.1 | 67 | 39 | 37 | 9 | 23 | 47 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.48 |