| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 23 | 23 | 9 | 3 | 4.04 | .304 | 1.30 | 8.4 | 3.3 | 5.9 | 140.1 | 131 | 71 | 63 | 14 | 51 | 91 | 0 | 0 | 0 | 0 | 13 | 2 | 6 | 4.14 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 23 | 23 | 12 | 6 | 3.35 | .268 | 1.08 | 6.7 | 3.1 | 6.0 | 142.1 | 105 | 56 | 53 | 9 | 49 | 95 | 2 | 0 | 0 | 1 | 17 | 2 | 2 | 3.56 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 23 | 23 | 7 | 6 | 5.35 | .323 | 1.40 | 10.2 | 2.4 | 7.0 | 133.0 | 150 | 82 | 79 | 17 | 36 | 103 | 2 | 0 | 0 | 0 | 10 | 4 | 0 | 4.02 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 22 | 22 | 8 | 4 | 4.38 | .337 | 1.50 | 7.9 | 5.6 | 3.8 | 123.1 | 108 | 67 | 60 | 7 | 77 | 52 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 4.85 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 55 | 0 | 2 | 4 | 2.16 | .255 | 1.03 | 6.1 | 3.3 | 8.4 | 58.1 | 39 | 14 | 14 | 2 | 21 | 54 | 0 | 29 | 2 | 0 | 0 | 0 | 1 | 2.67 |
| SU | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 91 | 52 | 0 | 4 | 0 | 2.27 | .232 | 0.89 | 5.9 | 2.1 | 9.1 | 67.1 | 44 | 17 | 17 | 5 | 16 | 68 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 2.70 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 59 | 0 | 5 | 2 | 3.04 | .300 | 1.27 | 6.6 | 4.9 | 9.5 | 74.0 | 54 | 26 | 25 | 5 | 40 | 78 | 0 | 1 | 5 | 0 | 0 | 1 | 3 | 3.43 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 42 | 0 | 6 | 5 | 5.40 | .344 | 1.55 | 8.6 | 5.4 | 8.3 | 48.1 | 46 | 30 | 29 | 8 | 29 | 44 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 5.21 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 43 | 0 | 3 | 0 | 3.14 | .281 | 1.15 | 6.9 | 3.6 | 9.2 | 48.2 | 37 | 21 | 17 | 4 | 19 | 49 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 3.29 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 32 | 0 | 2 | 2 | 2.37 | .313 | 1.32 | 7.8 | 4.0 | 7.8 | 38.0 | 33 | 14 | 10 | 4 | 17 | 33 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.13 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 5 | 0 | 0 | 0 | 3.05 | .295 | 1.26 | 5.4 | 6.3 | 6.3 | 20.2 | 12 | 7 | 7 | 0 | 14 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.70 |