| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 19 | 19 | 8 | 8 | 3.43 | .280 | 1.13 | 8.2 | 2.0 | 9.5 | 131.1 | 120 | 52 | 50 | 17 | 29 | 139 | 1 | 0 | 0 | 1 | 13 | 4 | 1 | 3.32 |
| SP | Rodon, C.Rodon, Carlos † >> | 32 | 2025 | L | 90 | 18 | 18 | 10 | 3 | 2.96 | .295 | 1.24 | 7.1 | 4.1 | 10.0 | 112.1 | 88 | 38 | 37 | 11 | 51 | 124 | 0 | 0 | 0 | 0 | 11 | 2 | 5 | 3.48 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 88 | 18 | 18 | 2 | 11 | 4.57 | .347 | 1.57 | 10.6 | 3.5 | 10.4 | 112.1 | 132 | 60 | 57 | 13 | 44 | 129 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 3.46 |
| CL | Miller, M.Miller, Mason † >> | 26 | 2025 | R | 98 | 39 | 0 | 2 | 2 | 2.58 | .268 | 1.04 | 5.2 | 4.3 | 11.1 | 38.1 | 22 | 11 | 11 | 1 | 18 | 47 | 0 | 27 | 1 | 0 | 0 | 2 | 1 | 2.45 |
| SU | Morejon, A.Morejon, Adrian # >> | 26 | 2025 | L | 87 | 39 | 0 | 1 | 1 | 4.73 | .330 | 1.43 | 9.7 | 3.2 | 8.1 | 40.0 | 43 | 21 | 21 | 6 | 14 | 36 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 4.35 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 71 | 36 | 0 | 4 | 1 | 3.58 | .303 | 1.30 | 8.3 | 3.7 | 10.7 | 27.2 | 25 | 11 | 11 | 7 | 11 | 32 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 5.22 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 63 | 41 | 0 | 3 | 1 | 4.23 | .341 | 1.52 | 9.0 | 5.0 | 9.7 | 27.2 | 27 | 13 | 13 | 5 | 15 | 29 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.04 |
| SP | Kelly, M.Kelly, Merrill >> | 36 | 2025 | R | 68 | 5 | 3 | 1 | 2 | 7.00 | .372 | 1.78 | 10.5 | 5.5 | 8.5 | 18.0 | 21 | 14 | 14 | 7 | 11 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8.00 |