| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 25 | 25 | 9 | 6 | 3.42 | .261 | 1.04 | 7.7 | 1.7 | 11.0 | 168.1 | 144 | 65 | 64 | 21 | 31 | 205 | 1 | 0 | 0 | 0 | 19 | 3 | 2 | 2.79 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 88 | 24 | 24 | 8 | 9 | 5.15 | .318 | 1.37 | 9.4 | 3.0 | 9.4 | 148.2 | 155 | 87 | 85 | 23 | 49 | 155 | 0 | 0 | 0 | 0 | 10 | 4 | 0 | 4.00 |
| SP | Nelson, R.Nelson, Ryne # >> | 27 | 2025 | R | 78 | 24 | 24 | 4 | 4 | 2.97 | .287 | 1.16 | 8.2 | 2.3 | 8.4 | 124.1 | 113 | 48 | 41 | 8 | 31 | 116 | 0 | 0 | 0 | 0 | 6 | 6 | 3 | 2.86 |
| SP | Kelly, M.Kelly, Merrill >> | 36 | 2025 | R | 68 | 24 | 23 | 8 | 9 | 5.92 | .355 | 1.62 | 11.4 | 3.2 | 8.1 | 117.0 | 148 | 79 | 77 | 26 | 41 | 105 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 5.25 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 56 | 25 | 22 | 2 | 4 | 6.32 | .384 | 1.82 | 11.7 | 4.7 | 9.3 | 94.0 | 122 | 71 | 66 | 23 | 49 | 97 | 0 | 0 | 2 | 0 | 0 | 5 | 4 | 5.84 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 78 | 78 | 0 | 10 | 5 | 5.89 | .338 | 1.51 | 10.9 | 2.8 | 10.8 | 94.2 | 114 | 62 | 62 | 27 | 29 | 113 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 5.32 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 73 | 0 | 7 | 5 | 4.29 | .313 | 1.36 | 8.0 | 4.2 | 10.4 | 84.0 | 75 | 45 | 40 | 9 | 39 | 97 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 3.51 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 67 | 66 | 0 | 8 | 6 | 4.22 | .323 | 1.41 | 9.3 | 3.3 | 6.9 | 79.0 | 82 | 39 | 37 | 11 | 29 | 61 | 0 | 2 | 2 | 0 | 0 | 2 | 3 | 4.44 |
| CL | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 72 | 0 | 6 | 5 | 3.60 | .304 | 1.25 | 7.9 | 3.4 | 11.0 | 80.0 | 70 | 33 | 32 | 6 | 30 | 98 | 0 | 24 | 7 | 0 | 0 | 5 | 1 | 2.84 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 67 | 0 | 2 | 1 | 4.64 | .314 | 1.32 | 8.0 | 4.0 | 9.4 | 75.2 | 67 | 42 | 39 | 15 | 33 | 78 | 0 | 2 | 7 | 0 | 0 | 4 | 1 | 5.00 |