| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 33 | 33 | 13 | 12 | 4.32 | .325 | 1.44 | 8.6 | 4.3 | 8.1 | 204.0 | 196 | 101 | 98 | 18 | 98 | 183 | 0 | 0 | 0 | 0 | 20 | 0 | 4 | 3.79 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 32 | 32 | 13 | 15 | 3.53 | .275 | 1.12 | 8.1 | 2.0 | 4.8 | 234.1 | 211 | 102 | 92 | 17 | 52 | 124 | 9 | 0 | 0 | 0 | 20 | 4 | 3 | 3.60 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 32 | 32 | 12 | 13 | 4.51 | .312 | 1.34 | 9.2 | 2.9 | 4.9 | 209.1 | 213 | 108 | 105 | 30 | 68 | 113 | 5 | 0 | 0 | 0 | 19 | 4 | 4 | 4.82 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 70 | 0 | 2 | 2 | 2.15 | .255 | 1.02 | 5.2 | 4.0 | 9.6 | 79.2 | 46 | 19 | 19 | 4 | 35 | 84 | 0 | 5 | 4 | 0 | 0 | 1 | 4 | 2.90 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 63 | 0 | 2 | 6 | 3.38 | .283 | 1.17 | 8.5 | 2.2 | 6.8 | 66.2 | 62 | 31 | 25 | 7 | 16 | 50 | 0 | 35 | 5 | 0 | 0 | 1 | 0 | 3.64 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 78 | 0 | 4 | 4 | 3.24 | .313 | 1.37 | 7.6 | 4.8 | 9.3 | 83.1 | 70 | 35 | 30 | 7 | 44 | 86 | 0 | 0 | 5 | 0 | 0 | 0 | 6 | 3.61 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 57 | 0 | 3 | 0 | 3.69 | .291 | 1.18 | 6.3 | 4.4 | 7.9 | 63.1 | 44 | 26 | 26 | 6 | 31 | 55 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 4.11 |
| RP | Nelson, J.Nelson, Jeff >> | 29 | 1995 | R | 17 | 47 | 0 | 3 | 1 | 3.34 | .293 | 1.24 | 8.9 | 2.3 | 7.3 | 62.0 | 61 | 23 | 23 | 7 | 16 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.63 |
| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 13 | 0 | 2 | 2 | 6.08 | .418 | 2.15 | 16.0 | 3.9 | 7.4 | 23.2 | 41 | 17 | 16 | 3 | 10 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4.35 |