| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 4 | 9 | 4.50 | .294 | 1.24 | 7.7 | 3.4 | 9.3 | 100.0 | 86 | 54 | 50 | 10 | 38 | 103 | 0 | 0 | 0 | 0 | 8 | 1 | 0 | 3.41 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 16 | 16 | 6 | 7 | 4.18 | .306 | 1.31 | 9.1 | 2.6 | 4.0 | 127.0 | 129 | 64 | 59 | 15 | 37 | 57 | 5 | 0 | 0 | 0 | 9 | 2 | 1 | 4.56 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 16 | 16 | 5 | 7 | 3.49 | .277 | 1.14 | 8.3 | 2.0 | 6.3 | 131.2 | 121 | 60 | 51 | 16 | 29 | 91 | 6 | 0 | 0 | 2 | 9 | 1 | 4 | 3.89 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 16 | 16 | 3 | 10 | 5.68 | .372 | 1.73 | 9.9 | 5.7 | 6.1 | 101.1 | 111 | 76 | 64 | 12 | 64 | 68 | 1 | 0 | 0 | 0 | 7 | 5 | 3 | 5.25 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 15 | 15 | 3 | 8 | 6.50 | .360 | 1.65 | 10.3 | 4.7 | 4.9 | 81.2 | 93 | 63 | 59 | 11 | 42 | 44 | 0 | 0 | 0 | 0 | 6 | 3 | 3 | 5.35 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 42 | 0 | 2 | 3 | 3.38 | .286 | 1.20 | 6.8 | 4.1 | 8.5 | 53.1 | 40 | 20 | 20 | 7 | 24 | 50 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.19 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 34 | 0 | 1 | 4 | 6.41 | .348 | 1.60 | 10.4 | 4.2 | 7.2 | 39.1 | 45 | 28 | 28 | 7 | 18 | 31 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 5.13 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 28 | 0 | 1 | 0 | 4.60 | .319 | 1.40 | 8.1 | 4.6 | 8.1 | 31.1 | 28 | 17 | 16 | 3 | 16 | 28 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.00 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 15 | 0 | 0 | 2 | 3.12 | .307 | 1.27 | 4.2 | 7.4 | 8.5 | 17.1 | 8 | 6 | 6 | 1 | 14 | 16 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.53 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 1 | 0 | 0 | 0 | 0.00 | .400 | 2.00 | 9.0 | 9.0 | 0.0 | 1.0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 8 | 0 | 2 | 2 | 5.87 | .387 | 1.83 | 10.8 | 6.0 | 3.6 | 15.1 | 18 | 10 | 10 | 4 | 10 | 6 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 7.87 |