| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 16 | 16 | 6 | 9 | 4.31 | .322 | 1.41 | 9.3 | 3.4 | 7.5 | 108.2 | 112 | 59 | 52 | 9 | 41 | 90 | 2 | 0 | 0 | 0 | 10 | 2 | 2 | 3.61 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 16 | 16 | 4 | 6 | 4.25 | .318 | 1.36 | 9.8 | 2.5 | 7.9 | 106.0 | 115 | 59 | 50 | 16 | 29 | 93 | 2 | 0 | 0 | 0 | 9 | 4 | 1 | 4.14 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 16 | 16 | 6 | 6 | 4.26 | .304 | 1.31 | 9.1 | 2.8 | 7.2 | 107.2 | 108 | 60 | 51 | 14 | 33 | 86 | 2 | 0 | 0 | 1 | 8 | 0 | 2 | 4.02 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 16 | 16 | 4 | 8 | 6.93 | .370 | 1.75 | 10.7 | 5.2 | 5.0 | 76.2 | 90 | 64 | 59 | 9 | 44 | 42 | 0 | 0 | 0 | 0 | 3 | 1 | 5 | 5.21 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 16 | 16 | 9 | 4 | 5.60 | .328 | 1.44 | 10.2 | 2.8 | 5.9 | 106.0 | 120 | 72 | 66 | 19 | 33 | 69 | 0 | 0 | 0 | 0 | 5 | 2 | 3 | 5.02 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 39 | 0 | 1 | 1 | 2.86 | .263 | 1.00 | 7.8 | 1.2 | 7.6 | 44.0 | 38 | 14 | 14 | 2 | 6 | 37 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 2.52 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 36 | 0 | 2 | 0 | 1.96 | .276 | 1.12 | 6.5 | 3.8 | 10.3 | 36.2 | 26 | 11 | 8 | 2 | 15 | 41 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.78 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 26 | 0 | 0 | 0 | 5.34 | .311 | 1.35 | 9.0 | 3.3 | 11.1 | 30.1 | 30 | 19 | 18 | 5 | 11 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.80 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 11 | 0 | 1 | 2 | 3.32 | .329 | 1.47 | 9.0 | 4.3 | 4.3 | 19.0 | 19 | 7 | 7 | 1 | 9 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.16 |