| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 33 | 33 | 15 | 9 | 2.79 | .252 | 1.00 | 6.6 | 2.3 | 10.5 | 219.0 | 161 | 75 | 68 | 18 | 57 | 255 | 1 | 0 | 0 | 1 | 24 | 3 | 0 | 2.56 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 92 | 33 | 33 | 15 | 11 | 3.39 | .277 | 1.14 | 7.8 | 2.4 | 5.4 | 236.0 | 205 | 92 | 89 | 24 | 64 | 141 | 9 | 0 | 0 | 2 | 22 | 2 | 4 | 3.97 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 32 | 32 | 11 | 9 | 4.30 | .330 | 1.43 | 8.6 | 4.4 | 7.5 | 184.1 | 175 | 90 | 88 | 19 | 89 | 153 | 0 | 0 | 0 | 0 | 18 | 8 | 3 | 4.26 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 30 | 30 | 13 | 10 | 3.97 | .288 | 1.20 | 8.1 | 2.6 | 7.9 | 201.2 | 182 | 89 | 89 | 27 | 59 | 177 | 6 | 0 | 0 | 2 | 17 | 4 | 4 | 3.93 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 94 | 76 | 0 | 11 | 5 | 3.38 | .276 | 1.14 | 6.3 | 4.0 | 8.3 | 101.1 | 71 | 38 | 38 | 8 | 45 | 93 | 0 | 4 | 7 | 0 | 0 | 0 | 1 | 3.52 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 62 | 0 | 3 | 3 | 3.34 | .301 | 1.28 | 7.0 | 4.6 | 7.5 | 67.1 | 52 | 28 | 25 | 6 | 34 | 56 | 0 | 3 | 3 | 0 | 0 | 1 | 5 | 4.06 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 47 | 0 | 5 | 2 | 3.08 | .304 | 1.29 | 9.0 | 2.8 | 9.0 | 52.2 | 52 | 19 | 18 | 7 | 16 | 52 | 0 | 1 | 3 | 0 | 0 | 1 | 2 | 3.73 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 23 | 0 | 1 | 2 | 2.67 | .289 | 1.15 | 5.0 | 5.3 | 6.0 | 27.0 | 15 | 8 | 8 | 4 | 16 | 18 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.59 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 60 | 0 | 3 | 6 | 4.32 | .332 | 1.46 | 7.9 | 5.3 | 7.1 | 58.1 | 51 | 30 | 28 | 3 | 34 | 46 | 0 | 37 | 9 | 0 | 0 | 2 | 1 | 3.95 |