| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 19 | 19 | 4 | 11 | 5.74 | .355 | 1.63 | 10.6 | 4.2 | 7.1 | 109.2 | 128 | 72 | 70 | 14 | 51 | 86 | 1 | 0 | 0 | 0 | 6 | 2 | 2 | 4.55 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 18 | 18 | 4 | 8 | 7.90 | .370 | 1.73 | 13.0 | 2.6 | 5.3 | 92.1 | 133 | 83 | 81 | 12 | 27 | 54 | 1 | 0 | 0 | 0 | 5 | 3 | 1 | 4.50 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 19 | 18 | 8 | 6 | 4.79 | .342 | 1.52 | 9.7 | 4.0 | 5.7 | 124.0 | 133 | 70 | 66 | 18 | 55 | 79 | 2 | 0 | 0 | 1 | 6 | 5 | 1 | 5.06 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 50 | 19 | 18 | 5 | 6 | 6.12 | .347 | 1.58 | 12.6 | 1.7 | 8.8 | 107.1 | 150 | 75 | 73 | 18 | 20 | 105 | 1 | 0 | 0 | 0 | 6 | 1 | 6 | 3.81 |
| SP | Greinke, Z.Greinke, Zack # >> | 32 | 2015 | R | 94 | 19 | 16 | 7 | 9 | 4.68 | .291 | 1.23 | 8.4 | 2.7 | 5.5 | 105.2 | 98 | 60 | 55 | 13 | 32 | 64 | 2 | 0 | 0 | 1 | 7 | 0 | 1 | 4.30 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 30 | 0 | 0 | 3 | 5.22 | .328 | 1.47 | 9.3 | 4.0 | 8.4 | 29.1 | 30 | 17 | 17 | 5 | 13 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.72 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 39 | 0 | 2 | 2 | 2.81 | .291 | 1.23 | 6.0 | 5.1 | 8.4 | 48.0 | 32 | 15 | 15 | 3 | 27 | 45 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.63 |
| CL | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 34 | 0 | 0 | 4 | 5.40 | .363 | 1.68 | 9.0 | 6.3 | 9.0 | 33.1 | 33 | 20 | 20 | 2 | 23 | 33 | 0 | 18 | 3 | 0 | 0 | 1 | 2 | 3.97 |
| SP | McQuillan, G.McQuillan, George >> | 23 | 1908 | R | 48 | 18 | 1 | 3 | 1 | 7.11 | .356 | 1.61 | 10.5 | 4.1 | 4.6 | 62.0 | 72 | 51 | 49 | 11 | 28 | 32 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 5.77 |