| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 34 | 34 | 13 | 13 | 4.29 | .309 | 1.33 | 8.1 | 3.9 | 9.6 | 224.1 | 201 | 110 | 107 | 27 | 97 | 240 | 1 | 0 | 0 | 0 | 21 | 3 | 3 | 3.76 |
| SP | Coveleski, S.Coveleski, Stan # >> | 28 | 1917 | R | 62 | 32 | 32 | 9 | 14 | 5.83 | .341 | 1.52 | 9.0 | 4.8 | 4.3 | 183.2 | 183 | 125 | 119 | 22 | 97 | 88 | 0 | 0 | 0 | 0 | 12 | 5 | 0 | 5.27 |
| SP | Tanana, F.Tanana, Frank # >> | 23 | 1976 | L | 58 | 31 | 31 | 13 | 15 | 4.38 | .283 | 1.18 | 8.2 | 2.4 | 6.1 | 232.0 | 212 | 120 | 113 | 40 | 61 | 157 | 11 | 0 | 0 | 0 | 13 | 2 | 2 | 4.70 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 80 | 0 | 5 | 5 | 3.53 | .303 | 1.30 | 8.8 | 3.0 | 8.1 | 109.2 | 107 | 44 | 43 | 9 | 36 | 98 | 0 | 9 | 6 | 0 | 0 | 0 | 3 | 3.27 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 79 | 0 | 4 | 5 | 3.34 | .298 | 1.22 | 7.3 | 3.8 | 8.4 | 99.2 | 80 | 37 | 37 | 9 | 42 | 92 | 0 | 9 | 4 | 0 | 0 | 5 | 4 | 3.75 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 56 | 0 | 4 | 1 | 2.84 | .269 | 1.06 | 5.2 | 4.4 | 9.0 | 69.2 | 40 | 26 | 22 | 7 | 34 | 69 | 0 | 7 | 2 | 0 | 0 | 3 | 2 | 3.93 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 51 | 0 | 4 | 1 | 3.27 | .299 | 1.22 | 6.7 | 4.3 | 8.7 | 63.1 | 47 | 24 | 23 | 10 | 30 | 61 | 0 | 4 | 1 | 0 | 0 | 4 | 5 | 4.75 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 23 | 0 | 0 | 1 | 5.02 | .301 | 1.29 | 7.7 | 4.2 | 4.5 | 28.2 | 24 | 16 | 16 | 0 | 13 | 14 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 3.39 |