| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 35 | 35 | 11 | 7 | 4.30 | .284 | 1.17 | 7.6 | 2.9 | 4.8 | 224.0 | 188 | 109 | 107 | 30 | 73 | 120 | 0 | 0 | 0 | 0 | 16 | 6 | 4 | 4.73 |
| SP | Sutton, D.Sutton, Don † # >> | 27 | 1972 | R | 82 | 35 | 35 | 16 | 13 | 4.43 | .297 | 1.25 | 9.0 | 2.3 | 5.1 | 243.2 | 242 | 126 | 120 | 33 | 62 | 137 | 11 | 0 | 0 | 3 | 20 | 5 | 7 | 4.47 |
| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 33 | 33 | 9 | 15 | 3.67 | .290 | 1.20 | 8.1 | 2.7 | 10.2 | 218.1 | 197 | 99 | 89 | 28 | 66 | 247 | 2 | 0 | 0 | 0 | 19 | 4 | 0 | 3.37 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 13 | 13 | 4.25 | .301 | 1.28 | 8.5 | 3.0 | 7.6 | 220.1 | 208 | 108 | 104 | 30 | 74 | 186 | 4 | 0 | 0 | 1 | 18 | 2 | 4 | 4.12 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 33 | 32 | 17 | 11 | 3.89 | .302 | 1.27 | 8.0 | 3.5 | 5.4 | 233.2 | 207 | 109 | 101 | 21 | 90 | 139 | 6 | 0 | 0 | 2 | 17 | 7 | 5 | 4.23 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 84 | 0 | 10 | 3 | 2.34 | .264 | 1.06 | 6.2 | 3.4 | 8.5 | 88.1 | 61 | 30 | 23 | 4 | 33 | 83 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 2.86 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 54 | 0 | 8 | 1 | 3.19 | .275 | 1.14 | 7.5 | 2.9 | 9.0 | 53.2 | 44 | 19 | 19 | 4 | 17 | 53 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 2.94 |
| CL | Davis, W.Davis, Wade † >> | 29 | 2015 | R | 89 | 61 | 0 | 1 | 2 | 2.39 | .249 | 0.98 | 5.4 | 3.5 | 7.2 | 60.1 | 36 | 16 | 16 | 4 | 23 | 48 | 0 | 48 | 5 | 0 | 0 | 1 | 2 | 3.47 |
| RP | Doolittle, S.Doolittle, Sean # >> | 31 | 2018 | L | 99 | 94 | 0 | 3 | 0 | 5.06 | .317 | 1.37 | 8.8 | 3.6 | 8.0 | 74.2 | 72 | 43 | 42 | 11 | 30 | 66 | 0 | 0 | 3 | 0 | 0 | 2 | 3 | 4.45 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 27 | 0 | 1 | 1 | 7.71 | .358 | 1.68 | 9.0 | 6.5 | 7.9 | 25.2 | 25 | 22 | 22 | 6 | 18 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6.52 |