| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 19 | 19 | 5 | 11 | 3.92 | .320 | 1.38 | 8.9 | 3.6 | 8.7 | 121.2 | 120 | 59 | 53 | 9 | 48 | 117 | 1 | 0 | 0 | 0 | 13 | 4 | 2 | 3.32 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 18 | 18 | 7 | 6 | 5.44 | .345 | 1.56 | 11.0 | 3.1 | 4.1 | 127.1 | 155 | 78 | 77 | 16 | 44 | 58 | 3 | 0 | 0 | 0 | 7 | 2 | 1 | 4.81 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 18 | 18 | 5 | 9 | 6.70 | .381 | 1.82 | 11.5 | 4.9 | 5.2 | 90.0 | 115 | 70 | 67 | 10 | 49 | 52 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 4.99 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 17 | 17 | 7 | 8 | 6.73 | .347 | 1.59 | 10.3 | 4.1 | 5.4 | 92.1 | 105 | 74 | 69 | 12 | 42 | 55 | 1 | 0 | 0 | 0 | 8 | 0 | 5 | 4.87 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 51 | 0 | 3 | 1 | 4.91 | .348 | 1.60 | 9.2 | 5.2 | 7.9 | 55.0 | 56 | 34 | 30 | 5 | 32 | 48 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 4.18 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 44 | 0 | 2 | 1 | 3.63 | .288 | 1.21 | 7.1 | 3.8 | 9.3 | 52.0 | 41 | 23 | 21 | 7 | 22 | 54 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.94 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 31 | 0 | 1 | 1 | 2.08 | .264 | 1.08 | 6.2 | 3.5 | 8.5 | 39.0 | 27 | 10 | 9 | 4 | 15 | 37 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.59 |
| RP | McMahon, D.McMahon, Don >> | 37 | 1967 | R | 44 | 26 | 0 | 1 | 0 | 2.55 | .275 | 1.09 | 6.8 | 3.4 | 3.8 | 24.2 | 18 | 7 | 7 | 3 | 9 | 10 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.04 |
| SP | Cuellar, M.Cuellar, Mike >> | 32 | 1969 | L | 44 | 18 | 0 | 2 | 1 | 7.12 | .393 | 1.95 | 10.8 | 6.9 | 5.1 | 30.1 | 36 | 26 | 24 | 4 | 23 | 17 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 5.90 |