| SP | Martinez, P.Martinez, Pedro >> | 37 | 2005 | R | 95 | 13 | 13 | 7 | 4 | 3.62 | .293 | 1.22 | 7.7 | 3.3 | 7.2 | 102.0 | 87 | 43 | 41 | 9 | 37 | 82 | 4 | 0 | 0 | 1 | 8 | 3 | 0 | 3.72 |
| SP | Patterson, J.Patterson, John >> | 30 | 2005 | R | 89 | 12 | 12 | 5 | 5 | 3.16 | .299 | 1.25 | 8.0 | 3.3 | 8.1 | 88.1 | 78 | 36 | 31 | 8 | 32 | 79 | 3 | 0 | 0 | 1 | 7 | 3 | 1 | 3.58 |
| SP | Wakefield, T.Wakefield, Tim >> | 42 | 2008 | R | 68 | 12 | 12 | 5 | 3 | 5.04 | .311 | 1.34 | 9.5 | 2.7 | 6.2 | 80.1 | 84 | 45 | 45 | 10 | 24 | 55 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 4.19 |
| RP | Kim, B.Kim, Byung-Hyun >> | 29 | 2003 | R | 81 | 32 | 0 | 2 | 1 | 2.85 | .283 | 1.14 | 8.8 | 1.5 | 6.7 | 47.1 | 46 | 15 | 15 | 6 | 8 | 35 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 3.81 |
| RP | Okajima, H.Okajima, Hideki >> | 33 | 2007 | L | 78 | 13 | 0 | 1 | 1 | 1.65 | .310 | 1.35 | 8.4 | 3.9 | 7.3 | 16.1 | 15 | 4 | 3 | 1 | 7 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 26 | 2007 | R | 91 | 12 | 0 | 2 | 0 | 1.23 | .421 | 2.18 | 10.3 | 10.3 | 6.4 | 7.1 | 8 | 3 | 1 | 1 | 8 | 5 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 6.86 |
| RP | Masterson, J.Masterson, Justin >> | 23 | 2008 | R | 56 | 5 | 0 | 0 | 1 | 1.59 | .320 | 1.41 | 9.0 | 5.4 | 7.2 | 5.2 | 5 | 1 | 1 | 0 | 3 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.20 |
| RP | Tallet, B.Tallet, Brian >> | 31 | 2007 | L | 55 | 10 | 0 | 0 | 0 | 3.21 | .333 | 1.36 | 9.0 | 3.2 | 6.4 | 14.0 | 14 | 5 | 5 | 3 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.86 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 28 | 2006 | R | 98 | 26 | 0 | 2 | 3 | 1.57 | .277 | 1.12 | 7.7 | 2.6 | 7.4 | 28.2 | 24 | 5 | 5 | 1 | 8 | 23 | 0 | 16 | 2 | 0 | 0 | 1 | 0 | 2.79 |