| SP | Martinez, P.Martinez, Pedro >> | 35 | 2005 | R | 99 | 34 | 34 | 16 | 14 | 3.79 | .286 | 1.17 | 7.6 | 2.9 | 7.4 | 268.2 | 227 | 114 | 113 | 32 | 86 | 221 | 8 | 0 | 0 | 0 | 18 | 10 | 2 | 3.98 |
| SP | Schilling, C.Schilling, Curt # >> | 40 | 2004 | R | 86 | 33 | 33 | 19 | 11 | 4.12 | .311 | 1.30 | 9.6 | 2.1 | 6.7 | 262.0 | 280 | 130 | 120 | 27 | 60 | 194 | 8 | 0 | 0 | 2 | 15 | 15 | 6 | 3.72 |
| SP | Patterson, J.Patterson, John # >> | 28 | 2005 | R | 88 | 33 | 33 | 10 | 16 | 4.62 | .310 | 1.30 | 8.8 | 2.9 | 8.1 | 229.2 | 225 | 124 | 118 | 22 | 74 | 205 | 2 | 0 | 0 | 1 | 15 | 11 | 5 | 3.57 |
| SP | Wakefield, T.Wakefield, Tim >> | 40 | 2005 | R | 57 | 31 | 31 | 7 | 14 | 4.86 | .317 | 1.35 | 8.6 | 3.6 | 6.1 | 220.1 | 209 | 122 | 119 | 24 | 89 | 150 | 2 | 0 | 0 | 1 | 16 | 9 | 3 | 4.39 |
| RP | Kim, B.Kim, Byung-Hyun >> | 27 | 2003 | R | 86 | 82 | 0 | 8 | 3 | 3.40 | .263 | 1.02 | 7.1 | 2.2 | 5.5 | 100.2 | 79 | 40 | 38 | 8 | 24 | 61 | 0 | 5 | 1 | 0 | 0 | 5 | 2 | 3.69 |
| RP | Williamson, S.Williamson, Scott >> | 30 | 2003 | R | 59 | 16 | 0 | 0 | 0 | 3.68 | .323 | 1.43 | 9.0 | 4.5 | 8.4 | 14.2 | 14 | 6 | 6 | 0 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2.64 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 99 | 69 | 0 | 9 | 7 | 3.12 | .269 | 1.07 | 6.6 | 3.0 | 7.8 | 75.0 | 55 | 27 | 26 | 3 | 25 | 65 | 0 | 42 | 6 | 0 | 0 | 3 | 0 | 2.91 |