| SP | Clemens, R.Clemens, Roger >> | 44 | 2005 | R | 96 | 33 | 33 | 12 | 9 | 4.07 | .316 | 1.36 | 8.1 | 4.2 | 7.3 | 212.1 | 191 | 97 | 96 | 20 | 98 | 173 | 0 | 0 | 0 | 0 | 16 | 5 | 8 | 4.05 |
| SP | Pettitte, A.Pettitte, Andy >> | 34 | 2005 | L | 90 | 33 | 33 | 11 | 11 | 4.80 | .309 | 1.31 | 9.2 | 2.6 | 6.2 | 217.1 | 223 | 117 | 116 | 26 | 62 | 150 | 3 | 0 | 0 | 2 | 16 | 7 | 2 | 4.13 |
| SP | Johnson, R.Johnson, Randy >> | 43 | 2005 | L | 81 | 32 | 32 | 11 | 15 | 5.06 | .337 | 1.51 | 10.5 | 3.1 | 6.5 | 201.0 | 234 | 118 | 113 | 22 | 69 | 145 | 0 | 0 | 0 | 0 | 14 | 4 | 4 | 4.07 |
| SP | Mussina, M.Mussina, Mike >> | 38 | 2003 | R | 79 | 32 | 32 | 11 | 12 | 7.00 | .366 | 1.70 | 12.2 | 3.2 | 7.9 | 137.2 | 185 | 113 | 107 | 17 | 49 | 120 | 0 | 0 | 0 | 0 | 6 | 4 | 1 | 4.02 |
| SP | Contreras, J.Contreras, Jose >> | 35 | 2005 | R | 64 | 32 | 32 | 4 | 10 | 6.07 | .348 | 1.56 | 9.9 | 4.1 | 5.7 | 135.0 | 148 | 94 | 91 | 19 | 62 | 86 | 0 | 0 | 0 | 0 | 5 | 6 | 4 | 5.07 |
| RP | Rivera, M.Rivera, Mariano >> | 37 | 2005 | R | 94 | 97 | 0 | 5 | 5 | 4.41 | .336 | 1.45 | 10.0 | 3.0 | 7.7 | 96.0 | 107 | 47 | 47 | 11 | 32 | 82 | 0 | 8 | 5 | 0 | 0 | 7 | 0 | 4.00 |
| RP | Heredia, F.Heredia, Felix >> | 31 | 2003 | L | 74 | 107 | 0 | 4 | 3 | 3.42 | .293 | 1.22 | 7.3 | 3.8 | 6.0 | 84.1 | 68 | 37 | 32 | 4 | 35 | 56 | 0 | 9 | 4 | 0 | 0 | 2 | 6 | 3.61 |
| RP | Proctor, S.Proctor, Scott >> | 29 | 2006 | R | 66 | 83 | 0 | 2 | 3 | 3.69 | .304 | 1.27 | 8.5 | 3.0 | 7.4 | 75.2 | 71 | 32 | 31 | 8 | 25 | 62 | 0 | 6 | 4 | 0 | 0 | 3 | 1 | 3.85 |
| RP | Hammond, C.Hammond, Chris >> | 40 | 2005 | L | 60 | 82 | 0 | 4 | 6 | 4.48 | .315 | 1.32 | 9.9 | 2.1 | 6.6 | 70.1 | 77 | 35 | 35 | 9 | 16 | 51 | 0 | 10 | 3 | 0 | 0 | 4 | 0 | 4.07 |
| SP | Hernandez, O.Hernandez, Orlando >> | 41 | 2004 | R | 57 | 28 | 0 | 5 | 3 | 6.84 | .391 | 1.90 | 11.9 | 5.3 | 6.4 | 102.2 | 135 | 87 | 78 | 12 | 60 | 73 | 0 | 0 | 1 | 0 | 0 | 3 | 2 | 4.95 |
| SP | Karstens, J.Karstens, Jeff >> | 24 | 2006 | R | 55 | 27 | 0 | 3 | 3 | 2.14 | .255 | 0.97 | 6.5 | 2.3 | 5.7 | 54.2 | 39 | 13 | 13 | 4 | 14 | 34 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 3.65 |