| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 8 | 6 | 3.37 | .253 | 0.99 | 6.4 | 2.6 | 9.5 | 120.1 | 85 | 50 | 45 | 15 | 34 | 126 | 0 | 0 | 0 | 0 | 12 | 3 | 0 | 3.45 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 18 | 18 | 7 | 6 | 4.30 | .302 | 1.26 | 7.7 | 3.6 | 7.5 | 115.0 | 99 | 62 | 55 | 14 | 46 | 96 | 1 | 0 | 0 | 1 | 8 | 4 | 1 | 4.22 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 17 | 17 | 6 | 7 | 4.41 | .295 | 1.21 | 8.4 | 2.6 | 7.5 | 112.1 | 104 | 57 | 55 | 13 | 32 | 93 | 1 | 0 | 0 | 0 | 6 | 5 | 2 | 3.84 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 16 | 16 | 8 | 3 | 3.35 | .308 | 1.28 | 6.9 | 4.6 | 4.6 | 107.1 | 82 | 42 | 40 | 6 | 55 | 55 | 3 | 0 | 0 | 0 | 12 | 6 | 2 | 4.41 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 31 | 0 | 2 | 2 | 1.89 | .296 | 1.26 | 6.3 | 5.2 | 9.8 | 33.1 | 23 | 8 | 7 | 2 | 19 | 36 | 0 | 19 | 1 | 0 | 0 | 0 | 2 | 3.33 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 92 | 56 | 0 | 8 | 2 | 3.94 | .304 | 1.27 | 7.7 | 3.8 | 9.2 | 48.0 | 41 | 21 | 21 | 6 | 20 | 49 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 3.96 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 41 | 0 | 3 | 0 | 3.00 | .308 | 1.22 | 7.3 | 3.7 | 9.0 | 27.0 | 22 | 11 | 9 | 1 | 11 | 27 | 0 | 3 | 0 | 0 | 0 | 3 | 3 | 3.04 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 25 | 0 | 0 | 1 | 4.71 | .315 | 1.38 | 7.3 | 5.1 | 10.3 | 21.0 | 17 | 12 | 11 | 4 | 12 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.90 |