| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 3 | 3 | 1 | 1 | 6.23 | .325 | 1.38 | 8.5 | 4.2 | 3.7 | 17.1 | 16 | 12 | 12 | 4 | 8 | 7 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 6.82 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 3 | 3 | 1 | 2 | 7.53 | .338 | 1.53 | 10.9 | 3.2 | 5.1 | 14.1 | 17 | 13 | 12 | 4 | 5 | 8 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6.64 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 8 | 0 | 2 | 0 | 0.77 | .205 | 0.69 | 4.1 | 2.5 | 9.0 | 11.2 | 5 | 1 | 1 | 0 | 3 | 11 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.09 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 8 | 0 | 0 | 1 | 2.57 | .300 | 1.29 | 3.9 | 7.7 | 9.0 | 7.0 | 3 | 4 | 2 | 0 | 6 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.57 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 4 | 0 | 0 | 0 | 1.93 | .481 | 2.79 | 18.0 | 11.3 | 13.5 | 4.2 | 8 | 1 | 1 | 0 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.75 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 2 | 0 | 0 | 0 | 11.57 | .500 | 2.57 | 13.5 | 13.5 | 13.5 | 2.1 | 3 | 3 | 3 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 12.50 |
| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 2 | 2 | 2 | 0 | 1.88 | .295 | 1.26 | 7.1 | 4.5 | 7.1 | 14.1 | 11 | 3 | 3 | 0 | 7 | 11 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2.93 |