| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 19 | 19 | 11 | 3 | 3.05 | .272 | 1.11 | 6.4 | 3.7 | 7.9 | 135.2 | 96 | 52 | 46 | 11 | 55 | 119 | 3 | 0 | 0 | 1 | 14 | 1 | 2 | 3.54 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 18 | 18 | 13 | 4 | 3.18 | .283 | 1.16 | 6.9 | 3.6 | 5.2 | 119.0 | 91 | 51 | 42 | 13 | 47 | 69 | 1 | 0 | 0 | 0 | 12 | 3 | 1 | 4.52 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 17 | 17 | 9 | 6 | 2.66 | .256 | 1.00 | 7.2 | 1.8 | 4.5 | 128.2 | 103 | 43 | 38 | 7 | 26 | 64 | 5 | 0 | 0 | 1 | 12 | 4 | 2 | 3.41 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 62 | 17 | 17 | 8 | 7 | 3.61 | .299 | 1.27 | 7.5 | 4.0 | 4.6 | 112.1 | 93 | 49 | 45 | 9 | 50 | 57 | 2 | 0 | 0 | 1 | 11 | 1 | 4 | 4.39 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 38 | 0 | 2 | 1 | 3.21 | .323 | 1.40 | 6.9 | 5.8 | 10.1 | 42.0 | 32 | 15 | 15 | 3 | 27 | 47 | 0 | 30 | 5 | 0 | 0 | 1 | 1 | 3.69 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 33 | 0 | 0 | 1 | 6.30 | .333 | 1.47 | 9.3 | 3.9 | 7.8 | 30.0 | 31 | 22 | 21 | 4 | 13 | 26 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.40 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 37 | 0 | 2 | 1 | 2.61 | .296 | 1.26 | 6.4 | 5.0 | 8.3 | 38.0 | 27 | 15 | 11 | 6 | 21 | 35 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.87 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 79 | 9 | 0 | 1 | 0 | 0.84 | .238 | 0.94 | 7.2 | 1.8 | 6.3 | 10.2 | 8 | 1 | 1 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.20 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 6 | 0 | 1 | 1 | 7.54 | .393 | 1.90 | 10.2 | 7.4 | 9.0 | 22.2 | 25 | 19 | 19 | 0 | 18 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.59 |