| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 26 | 26 | 11 | 9 | 4.44 | .310 | 1.34 | 9.0 | 3.1 | 8.6 | 178.1 | 178 | 94 | 88 | 18 | 61 | 171 | 2 | 0 | 0 | 0 | 12 | 1 | 2 | 3.44 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 25 | 25 | 10 | 6 | 4.30 | .293 | 1.24 | 8.3 | 2.8 | 9.3 | 157.0 | 145 | 80 | 75 | 22 | 49 | 163 | 1 | 0 | 0 | 0 | 12 | 1 | 5 | 3.70 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 23 | 23 | 9 | 10 | 4.80 | .358 | 1.65 | 11.0 | 3.8 | 6.3 | 146.1 | 179 | 91 | 78 | 11 | 62 | 102 | 2 | 0 | 0 | 0 | 12 | 4 | 6 | 3.94 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 98 | 44 | 0 | 2 | 4 | 3.48 | .275 | 1.14 | 7.0 | 3.3 | 8.4 | 44.0 | 34 | 20 | 17 | 6 | 16 | 41 | 0 | 32 | 8 | 0 | 0 | 0 | 0 | 4.00 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 49 | 0 | 1 | 1 | 3.00 | .274 | 1.13 | 6.3 | 3.8 | 9.7 | 54.0 | 38 | 18 | 18 | 5 | 23 | 58 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 3.33 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 60 | 0 | 4 | 3 | 3.38 | .261 | 1.03 | 7.3 | 2.1 | 8.9 | 74.2 | 60 | 30 | 28 | 9 | 17 | 73 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 3.38 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 30 | 0 | 3 | 2 | 3.99 | .290 | 1.23 | 6.5 | 4.7 | 9.3 | 29.1 | 21 | 18 | 13 | 3 | 15 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.83 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 21 | 0 | 0 | 0 | 4.03 | .331 | 1.48 | 8.7 | 4.7 | 8.4 | 29.0 | 28 | 14 | 13 | 2 | 15 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.59 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 15 | 0 | 0 | 2 | 7.07 | .333 | 1.50 | 8.4 | 5.1 | 7.7 | 14.0 | 13 | 11 | 11 | 2 | 8 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.86 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 22 | 0 | 1 | 1 | 6.23 | .345 | 1.58 | 11.4 | 2.8 | 4.5 | 26.0 | 33 | 20 | 18 | 4 | 8 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.92 |