| SP | Brown, K.Brown, Kevin † $ >> | 35 | 2000 | R | 91 | 21 | 21 | 13 | 5 | 3.60 | .287 | 1.18 | 8.6 | 2.1 | 7.3 | 137.2 | 131 | 58 | 55 | 18 | 32 | 111 | 0 | 0 | 0 | 0 | 13 | 3 | 1 | 3.85 |
| SP | Peavy, J.Peavy, Jake $ >> | 26 | 2007 | R | 89 | 20 | 20 | 1 | 13 | 6.02 | .343 | 1.52 | 10.0 | 3.8 | 9.0 | 113.2 | 125 | 80 | 76 | 18 | 48 | 113 | 0 | 0 | 0 | 0 | 8 | 5 | 3 | 4.48 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 81 | 19 | 19 | 7 | 6 | 5.05 | .336 | 1.49 | 9.6 | 3.8 | 8.8 | 114.0 | 122 | 65 | 64 | 16 | 48 | 112 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 4.20 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 19 | 19 | 9 | 5 | 4.39 | .332 | 1.45 | 10.1 | 3.0 | 7.0 | 127.0 | 142 | 68 | 62 | 23 | 42 | 99 | 1 | 0 | 0 | 1 | 10 | 5 | 4 | 4.91 |
| CL | Lidge, B.Lidge, Brad † >> | 28 | 2004 | R | 82 | 32 | 0 | 5 | 3 | 2.27 | .252 | 0.98 | 7.2 | 1.8 | 10.0 | 35.2 | 28 | 9 | 9 | 3 | 7 | 39 | 0 | 17 | 2 | 0 | 0 | 1 | 0 | 2.57 |
| SU | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 30 | 0 | 2 | 0 | 4.76 | .342 | 1.47 | 7.1 | 6.1 | 8.5 | 34.0 | 27 | 18 | 18 | 4 | 23 | 32 | 0 | 4 | 3 | 0 | 0 | 3 | 1 | 4.94 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 56 | 0 | 1 | 1 | 4.18 | .336 | 1.50 | 10.7 | 2.9 | 6.1 | 47.1 | 56 | 22 | 22 | 7 | 15 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.60 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 53 | 0 | 4 | 0 | 2.25 | .268 | 1.08 | 6.5 | 3.2 | 8.3 | 40.0 | 29 | 10 | 10 | 3 | 14 | 37 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.25 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 42 | 0 | 0 | 0 | 6.11 | .317 | 1.29 | 8.0 | 3.5 | 9.6 | 28.0 | 25 | 19 | 19 | 5 | 11 | 30 | 0 | 1 | 1 | 0 | 0 | 3 | 3 | 4.68 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 46 | 0 | 2 | 1 | 2.87 | .319 | 1.38 | 9.0 | 3.6 | 10.5 | 37.2 | 37 | 12 | 12 | 5 | 15 | 43 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.73 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 46 | 36 | 0 | 2 | 0 | 3.03 | .247 | 0.93 | 4.7 | 3.8 | 6.2 | 38.2 | 20 | 13 | 13 | 5 | 16 | 26 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 4.76 |