| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 32 | 32 | 9 | 12 | 4.13 | .337 | 1.49 | 9.4 | 4.1 | 9.7 | 200.2 | 209 | 105 | 92 | 31 | 90 | 216 | 1 | 0 | 0 | 0 | 16 | 7 | 2 | 4.31 |
| SP | Perez, O.Perez, Oliver # >> | 23 | 2004 | L | 76 | 32 | 32 | 14 | 9 | 5.11 | .335 | 1.48 | 9.0 | 4.3 | 9.3 | 193.2 | 194 | 117 | 110 | 30 | 92 | 199 | 0 | 0 | 0 | 0 | 15 | 7 | 3 | 4.50 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 31 | 31 | 14 | 12 | 5.96 | .340 | 1.51 | 10.2 | 3.4 | 5.9 | 167.2 | 190 | 115 | 111 | 29 | 64 | 110 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 5.18 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 53 | 30 | 30 | 8 | 17 | 6.58 | .367 | 1.74 | 11.6 | 4.1 | 6.8 | 157.1 | 202 | 125 | 115 | 32 | 72 | 118 | 1 | 0 | 0 | 0 | 8 | 0 | 2 | 5.52 |
| SU | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 76 | 0 | 3 | 2 | 3.67 | .290 | 1.17 | 8.1 | 2.5 | 10.6 | 68.2 | 61 | 30 | 28 | 12 | 19 | 80 | 0 | 3 | 3 | 0 | 0 | 4 | 4 | 3.96 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 41 | 79 | 0 | 3 | 7 | 4.16 | .314 | 1.33 | 8.7 | 3.2 | 7.4 | 67.0 | 65 | 36 | 31 | 13 | 24 | 55 | 0 | 2 | 6 | 0 | 0 | 3 | 0 | 5.09 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 56 | 0 | 1 | 0 | 3.53 | .308 | 1.29 | 8.6 | 3.0 | 8.1 | 51.0 | 49 | 22 | 20 | 4 | 17 | 46 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 3.33 |
| RP | Shields, S.Shields, Scot >> | 30 | 2005 | R | 32 | 65 | 0 | 3 | 4 | 4.67 | .342 | 1.51 | 9.0 | 4.7 | 9.3 | 61.2 | 61 | 32 | 32 | 10 | 32 | 63 | 0 | 1 | 1 | 0 | 0 | 3 | 5 | 4.79 |