| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 99 | 10 | 10 | 5 | 3 | 5.20 | .322 | 1.41 | 10.1 | 2.5 | 8.4 | 64.0 | 72 | 38 | 37 | 12 | 18 | 60 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 4.45 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 10 | 10 | 2 | 4 | 9.45 | .402 | 2.01 | 13.7 | 4.7 | 5.5 | 46.2 | 70 | 49 | 49 | 16 | 24 | 28 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 7.87 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 9 | 9 | 5 | 2 | 5.19 | .336 | 1.48 | 11.4 | 1.9 | 4.8 | 52.0 | 66 | 31 | 30 | 8 | 11 | 28 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.67 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 9 | 9 | 3 | 3 | 6.71 | .360 | 1.65 | 12.2 | 2.6 | 6.5 | 51.0 | 69 | 39 | 38 | 9 | 15 | 37 | 1 | 0 | 0 | 0 | 3 | 2 | 2 | 4.84 |
| CL | Gagne, E.Gagne, Eric $ >> | 27 | 2003 | R | 100 | 16 | 0 | 1 | 2 | 6.57 | .362 | 1.70 | 10.5 | 5.3 | 14.3 | 12.1 | 14 | 9 | 9 | 2 | 7 | 19 | 0 | 11 | 1 | 0 | 0 | 0 | 0 | 3.75 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 13 | 0 | 0 | 1 | 4.05 | .344 | 1.58 | 11.1 | 3.5 | 9.7 | 13.1 | 16 | 6 | 6 | 2 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 27 | 0 | 2 | 1 | 2.48 | .279 | 1.10 | 7.3 | 2.8 | 10.4 | 32.2 | 26 | 10 | 9 | 2 | 10 | 37 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 2.63 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 48 | 17 | 0 | 1 | 0 | 2.25 | .265 | 1.08 | 6.4 | 3.4 | 5.6 | 24.0 | 17 | 6 | 6 | 3 | 9 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 73 | 20 | 0 | 0 | 1 | 5.56 | .352 | 1.59 | 11.0 | 3.7 | 9.8 | 22.2 | 27 | 17 | 14 | 2 | 9 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.36 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 13 | 0 | 2 | 1 | 8.22 | .352 | 1.43 | 12.0 | 1.2 | 5.4 | 15.1 | 20 | 14 | 14 | 7 | 2 | 9 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 8.87 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 38 | 10 | 0 | 0 | 0 | 7.88 | .368 | 1.63 | 10.1 | 4.5 | 7.9 | 8.0 | 9 | 7 | 7 | 2 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.38 |